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. 2022 Oct 27;3(4):e177.
doi: 10.1002/mco2.177. eCollection 2022 Dec.

Pan-cancer analysis revealing DAAM1 as a novel predictive biomarker for PD-1/PD-L1 blockade in clear cell renal cell carcinoma

Jie Mei  1 , Honghong Fan  1 , Jiaofeng Zhou  2 , Dingwei Huang  2 , Junying Xu  1 , Yichao Zhu  2
Affiliations

Pan-cancer analysis revealing DAAM1 as a novel predictive biomarker for PD-1/PD-L1 blockade in clear cell renal cell carcinoma

Jie Mei et al. MedComm (2020). .
No abstract available

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Conflict of interest statement

The authors declare they have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Expression, prognostic value, and immuno‐correlation of Disheveled‐associated activator of morphogenesis 1 (DAAM1) in kidney renal clear cell carcinoma (KIRC). (A) Representative immunohistochemistry (IHC) staining revealing DAAM1 expression in tumor and para‐tumor tissues and semiquantitative analysis of DAAM1 expression in the HKidE180Su02 cohort. Magnification, 200×. A total of 150 tumor and 30 para‐tumor samples were included for analysis. The immunoreactivity score (IRS) equals to the percentages of positive cells multiplied with staining intensity. The percentage of positively stained cells was scored as 0–4: 0 (<5%), 1 (6%–25%), 2 (26%–50%), 3 (51%–75%), and 4 (>75%). The staining intensity was scored as 0–3: 0 (negative), 1 (weak), 2 (moderate), and 3 (strong). (B) Association between DAAM1 expression and survival status in KIRC patients. (C) Association between DAAM1 expression and overall survival in KIRC patients. DAAM1 low expression, n = 65; DAAM1 high expression, n = 85. (D) The correlation between DAAM1 and the levels of B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil, and dendritic cell. (E) Correlation analysis between DAAM1 and several immune checkpoints expressions. (F) Representative IHC staining revealing DAAM1 and programmed cell death 1 ligand 1 (PD‐L1) expressions in tumor tissues. (G) Correlation between DAAM1 and PD‐L1 expressions in the HKidE180Su02 cohort. (H and I) Association between DAAM1 expression and progression‐free survival in KIRC patients receiving Nivolumab or Avelumab + Axitini therapy. (H) DAAM1 low expression, n = 36; DAAM1 high expression, n = 71. (I) DAAM1 low expression, n = 104; DAAM1 high expression, n = 206.
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