Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 14:9:992576.
doi: 10.3389/fsurg.2022.992576. eCollection 2022.

A risk prediction model for evaluating thrombosis extension of muscle calf venous thrombosis after craniotomy

Juhua Li  1 , Huayu Chen  1 , Mei Liu  1 , Zheng Lin  1 , Xingzhen Ren  1 , Ying Wang  2 , Xingchen Zou  1 , Zejuan Gu  1
Affiliations

A risk prediction model for evaluating thrombosis extension of muscle calf venous thrombosis after craniotomy

Juhua Li et al. Front Surg. .

Abstract

Objective: To explore the risk factors of muscle calf venous thrombosis (MCVT) after craniotomy and construct a risk prediction model, so as to provide tool for evaluating the prognosis of MCVT after craniotomy.

Methods: Retrospective analysis was performed on the data of patients undergoing craniotomy complicated with MCVT from January 1, 2018 to December 31, 2020. A prediction model was established by Logistic regression, and the predictive efficacy of the model was tested by ROC curve. The accuracy of the risk model was evaluated by Hosmer-Lemeshow (H-L) test, and the model was verified internally by cross validation.

Results: Among the 446 patients who underwent craniotomy complicated with MCVT, 112 cases (25.11%) had thrombosis extension. D-dimer, Capirini scores, length of hospital stay, malignant tumor, fracture, use of dehydrating agents and hemostatic agents were independently related to thrombosis extension after craniotomy. The area under ROC curve (AUROC) of the prediction model was 0.918 (0.888, 0.942), and the sensitivity and specificity of the maximum Youden index were 85.3% and 78.2%, respectively. H-L test showed that the prediction model was accurate (χ 2 = 12.426, P = 0.133). The internal verification results of the prediction model showed that the AUROC value of the prediction model is 0.892.

Conclusion: The prediction model has a good prediction efficacy on the prognosis of post-craniotomy patients complicated with MCVT, and can be used as a tool to evaluate the risk of thrombosis extension.

Keywords: craniotomy; muscle calf venous thrombosis; nursing; prediction model; thrombosis extension.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The flow chart of our study.
Figure 2
Figure 2
The distinguishing ability of models was evaluated by ROC curve.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Khan NR, Patel PG, Sharpe JP, Lee SL, Sorenson J. Chemical venous thromboembolism prophylaxis in neurosurgical patients: an updated systematic review and meta-analysis. J Neurosurg. (2017) 129(4):1–10. 10.3171/2017.2.JNS162040 - DOI - PubMed
    1. Henry JC, Satiani B. Calf muscle venous thrombosis: a review of the clinical implications and therapy. Vasc Endovascular Surg. (2014) 48(5–6):396–401. 10.1177/1538574414541704 - DOI - PubMed
    1. Ro A, Kageyama N. Clinical significance of the soleal vein and related drainage veins, in calf vein thrombosis in autopsy cases with massive pulmonary thromboembolism. Ann Vasc Dis. (2016) 9(1):15–21. 10.3400/avd.oa.15-00088 - DOI - PMC - PubMed
    1. Porfidia A, Carnicelli A, Bonadia N, Pola R, Landolfi R. Controversies in venous thromboembolism: the unique case of isolated distal deep vein thrombosis. Intern Emerg Med. (2016) 11(6):775–9. 10.1007/s11739-016-1453-3 - DOI - PubMed
    1. Sales CM, Haq F, Bustami R, Sun F. Management of isolated soleal and gastrocnemius vein thrombosis. J Vasc Surg. (2010) 52(5):1251–4. 10.1016/j.jvs.2010.05.102 - DOI - PubMed

LinkOut - more resources