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Meta-Analysis
. 2022 Aug;76(4):292-296.
doi: 10.5455/medarh.2022.76.292-296.

Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

Sry Suryani Widjaja  1 , Rusdiana Rusdiana  1 , Lowilius Wiyono  2
Affiliations
Meta-Analysis

Exploring the Potential of Poguntano Extract on Diabetes Management: Systematic Review and Meta-Analysis

Sry Suryani Widjaja et al. Med Arch. 2022 Aug.

Abstract

Background: Poguntano (Picria fel-terrae Merr) is a traditional herb commonly used as a blood glucose lowering agent in Indonesia. However, the effectiveness of the herb has not yet been established.

Objective: This systematic review and meta-analysis aim to review the hypoglycemic effect of Poguntano extract in lowering plasma glucose levels.

Methods: We conducted a literature search using peer-reviewed databases for relevant articles on Poguntano extract in animal models of diabetes. The effect size was pooled using a random effect model.

Results: Two animal studies were included in the systematic review and meta-analysis. There was a significant difference in plasma glucose levels between diabetic control and rats treated with Puguntano extract (MD: 28.77; 95%CI: 6.20-51.34; p=0.01). There was no significant difference between non-diabetic control and Poguntano extract.

Conclusion: Poguntano extract lowers the blood glucose levels in diabetic rats compared to control.

Keywords: Animal; Diabetes Mellitus; Meta-Analysis; Poguntano.

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Conflict of interest statement

There are no conflicts of interest in the making of this manuscript.

Figures

Figure 1.
Figure 1.. The forest plot of blood glucose level between poguntano extract and nondiabetic control
Figure 2.
Figure 2.. The forest plot of blood glucose level between poguntano extract and diabetic control
See this image and copyright information in PMC

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