Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage

Abstract

Background: Targeting a cerebral perfusion pressure optimal for cerebral autoregulation (CPPopt) has been gaining more attention to prevent secondary damage after acute neurological injury. Brain tissue oxygenation (PbtO₂) can identify insufficient cerebral blood flow and secondary brain injury. Defining the relationship between CPPopt and PbtO₂ after aneurysmal subarachnoid hemorrhage may result in (1) mechanistic insights into whether and how CPPopt-based strategies might be beneficial and (2) establishing support for the use of PbtO₂ as an adjunctive monitor for adequate or optimal local perfusion.

Methods: We performed a retrospective analysis of a prospectively collected 2-center dataset of patients with aneurysmal subarachnoid hemorrhage with or without later diagnosis of delayed cerebral ischemia (DCI). CPPopt was calculated as the cerebral perfusion pressure (CPP) value corresponding to the lowest pressure reactivity index (moving correlation coefficient of mean arterial and intracranial pressure). The relationship of (hourly) deltaCPP (CPP-CPPopt) and PbtO₂ was investigated using natural spline regression analysis. Data after DCI diagnosis were excluded. Brain tissue hypoxia was defined as PbtO₂ <20 mmHg.

Results: One hundred thirty-one patients were included with a median of 44.0 (interquartile range, 20.8-78.3) hourly CPPopt/PbtO2 datapoints. The regression plot revealed a nonlinear relationship between PbtO₂ and deltaCPP (P<0.001) with PbtO₂ decrease with deltaCPP <0 mmHg and stable PbtO₂ with deltaCPP ≥0mmHg, although there was substantial individual variation. Brain tissue hypoxia (34.6% of all measurements) was more frequent with deltaCPP <0 mmHg. These dynamics were similar in patients with or without DCI.

Conclusions: We found a nonlinear relationship between PbtO₂ and deviation of patients' CPP from CPPopt in aneurysmal subarachnoid hemorrhage patients in the pre-DCI period. CPP values below calculated CPPopt were associated with lower PbtO₂. Nevertheless, the nature of PbtO₂ measurements is complex, and the variability is high. Combined multimodality monitoring with CPP/CPPopt and PbtO₂ should be recommended to redefine individual pressure targets (CPP/CPPopt) and retain the option to detect local perfusion deficits during DCI (PbtO₂), which cannot be fulfilled by both measurements interchangeably.

Keywords: brain; brain injuries, traumatic; hyperemia; infarction; partial pressure.

Figure 1.

The relationship between PbtO₂ and deltaCPP. A: Natural spline regression analysis of hourly deltaCPP and PbtO₂ pairs. B: PbtO₂, CPP, PRx values and data availability separated by 5mmHg deltaCPP bins. Black line indicates the proportion of brain tissue hypoxia (BTH) from all measurements within a bin. C+D: Data separated by patients without DCI (C) or with (D) DCI.