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. 2022 Oct;50(10):3000605221119657.
doi: 10.1177/03000605221119657.

The impact of bariatric surgery procedures on the modulation of cardiometabolic risk factors in patients with severe obesity: a 12-month follow-up

Mastaneh Rajabian Tabesh  1   2 , Maryam Abolhasani  3 , Mohammad Reza Zali  4 , Reza Bagheri  5 , Meysam Alipour  6 , Neda Cheraghloo  7 , Hamid Asadzadeh-Aghdaei  1 , Alexei Wong  8 , Hoda Zahedi  9 , Sara Hobaby  10 , Mahdi Shadnoush  1   11 , Makan Cheraghpour  1
Affiliations

The impact of bariatric surgery procedures on the modulation of cardiometabolic risk factors in patients with severe obesity: a 12-month follow-up

Mastaneh Rajabian Tabesh et al. J Int Med Res. 2022 Oct.

Abstract

Objective: To evaluate the effects of one anastomosis gastric bypass (OAGB), Roux-en-Y gastric bypass (RYGB), and sleeve gastrectomy (SG) on cardiometabolic risk factors (CMRFs) in patients with severe obesity.

Methods: This retrospective cohort study included patients with severe obesity who had undergone OAGB, RYGB, or SG between 2015 and 2017 and follow-up assessments over 12-months.

Results: Among 485 included patients, anthropometric measurements, body composition, fasting blood glucose (FBG), lipid profile, and comorbidities were significantly improved for all three procedures throughout the follow-up period. Weight, % total weight loss (%TWL), body mass index, fat mass and fat mass to fat-free mass ratio improvements were higher with RYGB and OAGB than SG. There were no significant differences between procedures in all other variables. A significant trend toward remission rate of dyslipidemia and type 2 diabetes mellitus was observed with all three procedures, with no significant difference between the three groups. %TWL statistically correlated with fat mass, FBG, and triglycerides.

Conclusions: OAGB, RYGB, and SG had a beneficial impact on CMRFs and comorbidities during 12 months of follow-up. Of note, RYGB and OAGB may result in better outcomes, particularly anthropometric and body composition indices. Further large-sample, long-term follow-up studies are required to expand on the present findings.

Keywords: Bariatric surgery; comorbidities; dyslipidemia; obesity; type 2 diabetes mellitus; weight loss.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
Comparison of the proportion of patients with type 2 diabetes mellitus or dyslipidemia following sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), or one anastomosis gastric bypass (OAGB) over a 12-month follow-up. Type 2 diabetes mellitus was defined as fasting blood glucose > 126 mg/dl; Dyslipidemia was defined as triglycerides > 150 mg/dl, low-density lipoprotein cholesterol > 130 mg/dl, and high-density lipoprotein cholesterol > 40 mg/dl in men and > 50 mg/dl in women. *P < 0.05, statistically significant difference versus baseline in each group.
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