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Comment
. 2022 Nov;33(11):2124-2125.
doi: 10.1681/ASN.2022070836. Epub 2022 Sep 9.

Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages-Too Many To Be True

Naomi S Shin  1 , Arnaud Marlier  2 , Leyuan Xu  3 , Natnael Doilicho  3 , Daniel Linberg  4 , Jiankan Guo  3 , Lloyd G Cantley  3
Affiliations
Comment

Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages-Too Many To Be True

Naomi S Shin et al. J Am Soc Nephrol. 2022 Nov.
No abstract available

Keywords: arginase-1; macrophage.

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Figures

Figure 1.
Figure 1.
Interstitial macrophages express Arg1. (A) Dot plot of Arg1 mRNA expression in the indicated cell types by single-cell RNA sequencing analysis performed on day 3 after IRI. (B) Dot plot of Lyz2 (gene name for lysozyme 2, also known as LysM) mRNA expression in the indicated cell types by single-cell RNA sequencing analysis performed on day 3 after IRI. (C) Confocal image of renal medulla stained with anti-megalin (red), anti-Arg1 (green), and 4′,6-diamidino-2-phenylindole (DAPI; blue) on day 7 after IRI. Megalin marks the apical membrane of the proximal tubule cells. Tubule outlines are indicated by the superimposed white dashed lines with tubule lumens indicated by “L.” Arrows indicate the interstitial macrophages expressing Arg1.
See this image and copyright information in PMC

Comment on

References

    1. Shin NS, Marlier A, Xu L, Doilicho N, Linberg D, Guo J, et al. : Arginase-1 is required for macrophage-mediated renal tubule regeneration. J Am Soc Nephrol 33: 1077–1086, 2022 - PMC - PubMed
    1. Zhang, et al. : Most arginase-1 positive cells are likely injured S3 proximal tubular cells carrying upregulated phagocytotic capacity rather than M2 macrophages. J Am Soc Nephrol 33: 2123–2124, 2022 - PMC - PubMed