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. 2023 May;62(5):664-671.
doi: 10.1111/ijd.16459. Epub 2022 Nov 1.

Epidemiological trends and survival outcomes for dermatofibrosarcoma protuberans of the head and neck region

Cammille C Go  1 , Gabriela M Lahaie Luna  1   2   3 , César A Briceño  1   2   3
Affiliations

Epidemiological trends and survival outcomes for dermatofibrosarcoma protuberans of the head and neck region

Cammille C Go et al. Int J Dermatol. 2023 May.

Abstract

Background: Given the rarity of dermatofibrosarcoma protuberans (DFSP) of the head and neck, the incidence and prognosis specific to this region are poorly defined. The purpose of this study was to determine epidemiology, clinicopathological characteristics, and prognostic factors of patients with DFSP of the head and neck region, using the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: A cohort analysis was performed for primary head and neck DFSP reported to the SEER database between 2000 and 2018. Overall survival was determined using Kaplan-Meier analysis while Cox regression modeling was used to examine predictive factors.

Results: A total of 681 cases were reported to the SEER database between 2000 and 2018. Incidence rates decreased over time. Overall survival was 94%, and disease-specific survival was 99% at 5 years. Cases of head and neck DFSP were found to occur more frequently in males. There was no difference in incidence rates between White patients and Black patients. Age ≥ 60 years old, tumor size, and living location were the most significant predictors of overall survival.

Conclusions: This analysis of DFSP of the head and neck demonstrates a downward trend in incidence, higher age-standardized incidence in males, and similar race-based incidences, which differs from data reported on DFSP of other anatomic locations.

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References

    1. Simon MP, Pedeutour F, Sirvent N, Grosgeorge J, Minoletti F, Coindre JM, et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL 1A 1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet 1997;15(1):95-8.
    1. Kreicher KL, Kurlander DE, Gittleman HR, Barnholtz-Sloan JS, Bordeaux JS. Incidence and survival of primary dermatofibrosarcoma protuberans in the United States. Dermatol Surg. 2016;42:S24-31.
    1. Criscione VDVD, Weinstock MA. Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002. J Am Acad Dermatol. 2007;56(6):968-73.
    1. Ugurel S, Kortmann RD, Mohr P, Mentzel T, Garbe C, Breuninger H, et al. S1 guidelines for dermatofibrosarcoma protuberans (DFSP) - update 2018. J Dtsch Dermatol Ges. 2019;17(6):663-8.
    1. Foroozan M, Sei J, Amini M, Beauchet A, Saiag P. Efficacy of Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: systematic review. Arch Dermatol. 2012;148(9):1055-64.

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