Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Cristiano B Campanholo¹, Ajesh B Maharaj², Nadia Corp³, Stacie Bell⁴, Luisa Costa⁵, Kurt de Vlam⁶, Nicola J Gullick⁷, Majed Khraishi⁸, Mitsumasa Kishimoto⁹, Natalia Palmou-Fontana¹⁰, Soumya Reddy¹¹, Raffaele Scarpa¹², Luis Vega¹³, Gleison Vieira Duarte¹⁴, Devy Zisman¹⁵, Danielle A van der Windt¹⁶, Mehmet T Duruoz¹⁷, Alexis Ogdie¹⁸

Affiliations

¹ C.B. Campanholo, MD, Santa Casa de São Paulo, São Paulo, Brazil.
² A.B. Maharaj, PhD, MBBS, Life Westville Hospital, Life Healthcare, Westville, South Africa.
³ N. Corp, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK.
⁴ S. Bell, PhD, National Psoriasis Foundation, Portland, Oregon, USA.
⁵ L. Costa, MD, PhD, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
⁶ K. de Vlam, MD, PhD, Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium.
⁷ N.J. Gullick, PhD, BMBS, Department of Rheumatology, University Hospitals Coventry & Warwickshire, and Warwick Medical School, University of Warwick, UK.
⁸ M. Khraishi, MD, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
⁹ M. Kishimoto, MD, PhD, Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan.
¹⁰ N. Palmou-Fontana, MD, PhD, Rheumatology Deparment, Marqués de Valdecilla University Hospital, Cantabria, Spain.
¹¹ S. Reddy, MD, New York University Grossman School of Medicine, New York City, New York, USA.
¹² R. Scarpa, MD, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
¹³ L. Vega, MD, Section of Rheumatology, Central Hospital of Peruvian Air Force, Lima, Peru.
¹⁴ G.V. Duarte, MD, PhD, Dermatology Division at IBIS, Instituto Bahiano de Imunoterapia, Salvador, Brazil.
¹⁵ D. Zisman, MD, Rheumatology Unit, Carmel Medical Center, and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
¹⁶ D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK.
¹⁷ M.T. Duruoz, Rheumatology Division, PMR Department, Marmara University School of Medicine, Istanbul, Turkey.
¹⁸ A. Ogdie, MD, MSCE, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ogdiea@pennmedicine.upenn.edu.

PMID: 36319003
DOI: 10.3899/jrheum.220310

Free article

Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

Cristiano B Campanholo et al. J Rheumatol. 2023 Mar.

Free article

. 2023 Mar;50(3):426-432.

doi: 10.3899/jrheum.220310. Epub 2022 Nov 1.

Authors

Affiliations

¹ C.B. Campanholo, MD, Santa Casa de São Paulo, São Paulo, Brazil.
² A.B. Maharaj, PhD, MBBS, Life Westville Hospital, Life Healthcare, Westville, South Africa.
³ N. Corp, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK.
⁴ S. Bell, PhD, National Psoriasis Foundation, Portland, Oregon, USA.
⁵ L. Costa, MD, PhD, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
⁶ K. de Vlam, MD, PhD, Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium.
⁷ N.J. Gullick, PhD, BMBS, Department of Rheumatology, University Hospitals Coventry & Warwickshire, and Warwick Medical School, University of Warwick, UK.
⁸ M. Khraishi, MD, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
⁹ M. Kishimoto, MD, PhD, Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan.
¹⁰ N. Palmou-Fontana, MD, PhD, Rheumatology Deparment, Marqués de Valdecilla University Hospital, Cantabria, Spain.
¹¹ S. Reddy, MD, New York University Grossman School of Medicine, New York City, New York, USA.
¹² R. Scarpa, MD, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
¹³ L. Vega, MD, Section of Rheumatology, Central Hospital of Peruvian Air Force, Lima, Peru.
¹⁴ G.V. Duarte, MD, PhD, Dermatology Division at IBIS, Instituto Bahiano de Imunoterapia, Salvador, Brazil.
¹⁵ D. Zisman, MD, Rheumatology Unit, Carmel Medical Center, and the Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.
¹⁶ D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK.
¹⁷ M.T. Duruoz, Rheumatology Division, PMR Department, Marmara University School of Medicine, Istanbul, Turkey.
¹⁸ A. Ogdie, MD, MSCE, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ogdiea@pennmedicine.upenn.edu.

PMID: 36319003
DOI: 10.3899/jrheum.220310

Abstract

Objective: The 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations provide an evidence-based guide for selecting therapy based on the individual's disease features. Beyond the disease features and associated conditions (eg, uveitis and inflammatory bowel disease), comorbidities play an important role in selecting therapy for an individual patient.

Methods: We performed a systematic literature review. We examined the available evidence to inform treatment selection based on the presence or absence of comorbidities in psoriatic arthritis (PsA).

Results: Common comorbidities in PsA that may affect treatment selection include presence of baseline cardiovascular disease (CVD) or high risk for CVD, obesity and metabolic syndrome, liver disease, mood disorders, including depression in particular, chronic infections, malignancies, osteoporosis, and fibromyalgia and/or central sensitization.

Conclusion: Comorbidities may influence both the effectiveness of a given therapy but also the potential for adverse events. It is important to assess for the presence of comorbidities prior to therapy selection.

Keywords: GRAPPA; comorbidities; psoriatic arthritis; treatments.

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Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

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Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations

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Abstract

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Medical

Research Materials

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