Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 1;12(1):18360.
doi: 10.1038/s41598-022-23316-4.

Survival rate and predictors of mortality among TB/HIV co-infected adult patients: retrospective cohort study

Mesfin Esayas Lelisho  1 , Teramaj Wongel Wotale  2 , Seid Ali Tareke  3 , Bizuwork Derebew Alemu  3 , Sali Suleman Hassen  3 , Daniel Melese Yemane  4 , Birhanu Bedada Korsa  3 , Namso Geda Bedaso  5
Affiliations

Survival rate and predictors of mortality among TB/HIV co-infected adult patients: retrospective cohort study

Mesfin Esayas Lelisho et al. Sci Rep. .

Abstract

Nowadays, Tuberculosis remains the major cause of HIV-associated mortality, which accounts for 1 out of every 5 HIV-related mortality worldwide. This study aimed to determine the survival rate and predictors of mortality among TB/HIV co-infected patients. An institution-based retrospective cohort study was undertaken on adult TB/HIV co-infected individuals between 1st February 2014 and 30th January 2022 at Mettu Karl Referral Hospital. A Cox regression model was used to identify predictors of survival time to death among TB/HIV co-infected patients. This study comprised 402 TB and HIV co-infected adult patients. Among these, 84 (20.9%) died, and 318 (79.1%) were censored. The study subjects have been followed up for 6920 person-months with an overall median survival time of 17.6 months. The overall incidence rate was 12.1 per 1000 person months [95% CI: 9.77-14.98]. The results of a multivariable Cox regression analysis showed that being at an older age, urban residence, WHO clinical stage II & IV, CD4 count of ≥ 200 cells/mm3, bedridden functional status, using INH, and using CPT were associated with the survival time of TB and HIV co-infected patients at a significance level of alpha = 0.05. This retrospective study found that high mortality of TB/HIV co-infected patients occurred in the earlier months of treatment initiation. Close monitoring of patients with low CD4, who do not utilize CPT, who are in advanced WHO stages, and who have poor functional levels can help them improve their health and live longer.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Overall enrollment of the adult patients co-infected with TB/HIV on ART at Mettu Karl Hospital, Ethiopia, 2014–2022 (n = 402).
Figure 2
Figure 2
Overall Kaplan–Meier curve of survival proportion of TB/HIV co-infected adults on ART at Mettu Karl Referral Hospital, Ethiopia, 2014–2022 (n = 402).
Figure 3
Figure 3
Survival curves for CD4 count/mm3, and CPT use of TB, and HIV co-infected adults who were on ART at Mettu Karl Referral Hospital, Ethiopia, 2014–2022 (n = 402).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tola A, Mishore KM, Ayele Y, Mekuria AN, Legese N. Treatment outcome of tuberculosis and associated factors among TB-HIV Co-infected patients at public hospitals of Harar town, Eastern Ethiopia. A five-year retrospective study. BMC Public Health. 2019;19:1–12. doi: 10.1186/s12889-019-7980-x. - DOI - PMC - PubMed
    1. Mugusi FM, Mehta S, Villamor E, Urassa W, Saathoff E, Bosch RJ, Fawzi WW. Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health. 2009;9:1–8. doi: 10.1186/1471-2458-9-409. - DOI - PMC - PubMed
    1. Gezae KE, Abebe HT, Gebretsadik LG, Gebremeskel AK. Predictors of time to death among TB/HIV co-infected adults on ART at two governmental hospitals in Mekelle, Ethiopia, 2009–2016: A retrospective cohort study. Ann. Infect. Dis. Epidemiol. 2020;2020(5):1049.
    1. Wondimu W, Dube L, Kabeta T. Factors affecting survival rates among adult TB/hiv co-infected patients in Mizan Tepi University teaching hospital, South West Ethiopia. HIV/AIDS (Auckland, NZ) 2020;12:157. - PMC - PubMed
    1. Kwan CK, Ernst JD. HIV and tuberculosis: A deadly human syndemic. Clin. Microbiol. Rev. 2011;24:351–376. doi: 10.1128/CMR.00042-10. - DOI - PMC - PubMed