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. 2023 Jan;50(1):173-183.
doi: 10.1007/s11033-022-07907-y. Epub 2022 Nov 1.

Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients

Samaneh Ramezani  1 , Fatemeh Ezzatifar  2   3 , Tahereh Hojjatipour  4 , Maryam Hemmatzadeh  5 , Arezoo Gowhari Shabgah  6 , Jamshid Gholizadeh Navashenaq  7 , Saeed Aslani  8 , Navid Shomali  5 , Mohsen Arabi  9 , Farhad Babaie  10 , Farhad Jadidi-Niaragh  11   12 , Ramin Hosseinzadeh  8 , Fahimeh Feizisani  13 , Sara Khodayar  14 , Roghaiyeh Safari  15   16 , Hamed Mohammadi  17   18
Affiliations

Association of the matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of coronavirus disease 2019 (COVID-19); implications of contribution for development of neurological symptoms in the COVID-19 patients

Samaneh Ramezani et al. Mol Biol Rep. 2023 Jan.

Erratum in

Abstract

Background: Seemingly, the Matrix metalloproteinases (MMPs) play a role in the etiopathogenesis of coronavirus disease 2019 (COVID-19). Here in this study, we determined the association of MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms with the risk of COVID-19, especially in those with neurological syndrome (NS).

Methods: We enrolled 500 patients with COVID-19 and 500 healthy individuals. To genotype the target SNPs, the Real-time allelic discrimination technique was used. To determine serum levels of MMPs, Enzyme-linked immunosorbent assay (ELISA) was exerted.

Results: The MMP9 gene rs3918242 and MMP3 gene rs3025058 SNP were significantly associated with increased COVID-19 risk and susceptibility to COVID-19 with NS. The serum level of MMP-9 and MMP-3 was significantly higher in COVID-19 cases compared with the healthy controls. Serum MMP-9 and MMP-3 levels were also higher in COVID-19 subjects with NS in comparison to the healthy controls. The polymorphisms in MMP genes were not associated with serum level of MMPs.

Conclusion: MMP9 and MMP3 gene polymorphisms increases the susceptibility to COVID-19 as well as COVID-19 with neurologic syndrome, but they probably have no role in the regulation of serum MMP-9 and MMP-3 levels.

Keywords: Central nervous system; Coronavirus disease 2019; Genetic polymorphism; Matrix metalloproteinases; Neurological symptoms.

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Conflict of interest statement

The authors declare that they have no conflicting interests.

Figures

Fig. 1
Fig. 1
Bar charts demonstrate the serum concentration of MMP-9, MMP-3, and MMP-2 in the COVID-19 subjects and healthy controls (A, B, C). The comparison of the serum levels of MMP-9, MMP-3, and MMP-2 in the COVID-19 patients with neurologic syndrome (NS) compared with healthy controls (D, E, F). The mean comparisons were done by statistical test of Mann-Whitney’s U test (** shows P < 0.01, *** shows P < 0.001; ns, non-significant)
Fig. 2
Fig. 2
Bar graphs show the serum concentration of MMP-9, MMP-3, and MMP-2 in the COVID-19 subjects with three different genotypes for MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms, respectively (A, B, C). The comparison of the serum levels of MMP-9, MMP-3, and MMP-2 in the COVID-19 subjects with neurologic syndrome (NS) harboring three different genotypes for MMP9 rs3918242, MMP3 rs3025058, and MMP2 rs243865 polymorphisms, respectively (D, E, F). The mean comparisons were done using the statistical test of Kruskal-Wallis (ns, non-significant)
See this image and copyright information in PMC

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