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Meta-Analysis
. 2022 Nov 1;12(1):18348.
doi: 10.1038/s41598-022-22037-y.

Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis

Ken Nagino  1   2   3 , Jaemyoung Sung  2   3 , Genko Oyama  4 , Motoshi Hayano  5 , Nobutaka Hattori  4   6 , Yuichi Okumura  2   3 , Kenta Fujio  2   3 , Yasutsugu Akasaki  2   3 , Tianxiang Huang  2   3 , Akie Midorikawa-Inomata  1 , Keiichi Fujimoto  2   3 , Atsuko Eguchi  1 , Shokirova Hurramhon  2   3 , Maria Miura  2   3 , Mizu Ohno  2   3 , Kunihiko Hirosawa  2   3 , Yuki Morooka  2   3 , Akira Murakami  2   3 , Hiroyuki Kobayashi  1 , Takenori Inomata  7   8   9   10
Affiliations
Meta-Analysis

Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis

Ken Nagino et al. Sci Rep. .

Abstract

We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson's disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian-Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.

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Conflict of interest statement

T.I. reported receiving grants from Johnson & Johnson Vision Care, SEED Co., Ltd, Novartis Pharma K.K., and Kowa Company, Ltd. outside the submitted work, as well as personal fees from Santen Pharmaceutical Co., Ltd., and InnoJin, Inc. Y.O. and A.M.I. reported receiving personal fees from InnoJin, Inc. outside the submitted work. The remaining authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of study selection. DED dry eye disease.
Figure 2
Figure 2
Forest plot of the prevalence of subjective DED symptoms in patients with PD. DED dry eye disease, PD Parkinson’s disease, CI confidence interval.
Figure 3
Figure 3
Forest plot of the blink rate of patients with PD versus controls. (a) Forest plot of the blink rate. (b) Forest plot of the blink rate according to subgroups based on HYS scores. PD Parkinson’s disease, SD standard deviation, CI confidence interval, HYS Hoehn and Yahr Scale.
Figure 4
Figure 4
Forest plot of the corneal thickness of patients with PD versus controls. PD Parkinson’s disease, SD standard deviation, CI confidence interval.
Figure 5
Figure 5
Forest plot of DED clinical examinations in patients with PD versus controls. (a) Forest plot of TFBUT. (b) Forest plot of TFBUT according to subgroups based on HYS scores. (c) Forest plot of scores of Schirmer test I without anesthesia. (d) Forest plot of Schirmer test I scores with anesthesia. PD Parkinson’s disease, SD standard deviation, CI confidence interval, HYS Hoehn and Yahr Scale, TFBUT tear film breakup time.
See this image and copyright information in PMC

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