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Observational Study
. 2022 Nov 1;23(1):350.
doi: 10.1186/s12882-022-02973-7.

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

Chen Fu  1 , Fengqin Wu  2 , Fang Chen  1 , Enhong Han  2 , Yuehua Gao  3 , Yongxing Xu  4
Affiliations
Observational Study

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

Chen Fu et al. BMC Nephrol. .

Abstract

Background: Muscle dysfunction is prevalent in dialysis patients. Gait speed and handgrip strength are simple and reliable methods of assessing muscle function. Numerous observational studies have linked 25-hydroxy vitamin D[25(OH)D] status with gait speed and handgrip strength in populations without kidney diseases. This study aimed to evaluate the potential associations of 25(OH)D status with gait speed and handgrip strength in patients on hemodialysis.

Methods: In this observational cross-sectional study, demographic data, biological data, and dialysis parameters were collected. Gait speed and handgrip strength were measured. Multiple linear regression and logistic regression analysis were used to investigate the relationship of 25(OH)D status with gait speed and handgrip strength after adjusting for potential confounders.

Results: Overall, a total of 118 participants undergoing hemodialysis were included. Seventy-one (60.2%) participants were male. The median 25(OH)D status in participants was 11.58 (interquartile range: 8.51 to 15.41) ng/ml. When controlling for age, gender, dialysis vintage, and other confounders with a p-value < 0.15 in univariate analyses, 25(OH)D was significantly positively associated with gait speed (β = 0.16, 95% CI 0.05 to 0.28, p = 0.006) and handgrip strength (β = 3.83, 95% CI 1.09 to 6.56, p = 0.007).

Conclusion: Our study showed that 25(OH)D status seemed to be associated with gait speed and handgrip strength in patients on hemodialysis. However, these results were not robust. The relationships between 25(OH)D status and gait speed and handgrip should be further explored.

Keywords: 25-hydroxy vitamin D; Gait speed; Handgrip strength; Hemodialysis.

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Conflict of interest statement

All authors declare that they have no conflicts of interest that might be relevant to the contents of this manuscript.

Figures

Fig. 1
Fig. 1
The bivariate analysis showed a significant relationship of vitamin D status with gait speed and handgrip strength. (a) Association between 25(OH)D and gait speed. (b) Association between 25(OH)D and handgrip strength. 25(OH)D had positively skewed distributions and were log-transformed
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