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. 2022 Sep 21:21:1222-1230.
doi: 10.17179/excli2022-5078. eCollection 2022.

Intraspecific differences in Androctunus crassicauda venom and envenomation symptoms

Mehdi Safdarian  1 , Babak Vazirianzadeh  2 , Ahmad Ghorbani  3 , Narges Pashmforoosh  3 , Masoumeh Baradaran  3
Affiliations

Intraspecific differences in Androctunus crassicauda venom and envenomation symptoms

Mehdi Safdarian et al. EXCLI J. .

Abstract

Envenomation by Androctunus crassicauda is very frequent in Iran, especially in the south-west. This scorpion is one of the six scorpions whose venom is used to prepare anti-venom. Using HPLC, we discovered venom components of A. crassicauda varies from one specimen to another depending on geographical location, and this result is confirmed by those first found in various symptoms of A. crassicauda sting in envenomed persons from two separate geographical places (north and south of Khuzestan province). There was a significant relationship between symptoms and location of envenomation by A. crassicauda. Muscle spasm was more dominant in envenomed people from Northern cities, and venom chromatogram analysis showed the presence of at least six main sharp peaks in Northern A. crassicauda rather than Southern A. crassicauda. It shows intraspecific differences in venom of A. crassicauda that must be considered in treatment of stung people from different geographical locations as well as in the preparation of anti-venom. See also Figure 1(Fig. 1).

Keywords: Androctunus crassicauda; envenomation symptoms; intraspecific differences; venom difference.

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Figures

Table 1
Table 1. Data from stung people by A. crassicauda referred to Razi Hospital
Table 2
Table 2. Relationship between residency of patients and five variables
Figure 1
Figure 1. Figure 1: Graphical abstract
Figure 2
Figure 2. HPLC chromatograms for A. crassicauda venom living in northern Khuzestan (NAc) and A. crassicauda living in southern Khuzestan (SAc). The main differences between the two chromatograms are highlighted.
See this image and copyright information in PMC

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