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. 2022 Apr-Jun;48(2):187-195.
doi: 10.12865/CHSJ.48.02.08. Epub 2022 Jun 30.

Clinicopathological Prognostic Parameters of Endometrioid Endometrial Carcinomas

Ileana Drocaş  1 , Ştefania Crăiţoiu  2 , Alex Emilian Stepan  3 , Ioan Andrei Drocaş  4 , Mioara Desdemona Stepan  5
Affiliations

Clinicopathological Prognostic Parameters of Endometrioid Endometrial Carcinomas

Ileana Drocaş et al. Curr Health Sci J. 2022 Apr-Jun.

Abstract

Endometrioid endometrial carcinomas (EEC) are common malignant lesions of the female genital tract, with incidence and risk factors that raise issues to improve histopathological prognostic factors. The study included 50 EEC cases, for which the clinicopathological parameters represented by age, risk factors, tumor grade, histological differences, invasion pattern, tumor stage and association of endometrial hyperplasia were analyzed statistically. The results indicated the predominance of EEC in the 7th decade of life, with associated risk factors (78%), more frequently well differentiated (52%), with no other specifications related to differentiation (NOS, 60%), with irregular invasion pattern (66%) in<50% of the myometrial wall (48%). Irregular pattern, microcystic, elongated, and fragmented (MELF) pattern and myoinvasion associated with vascular invasion (MVI) pattern were significantly associated with high grade and advanced stage tumors. With the exception of EEC-NOS and squamous differentiation, all other tumors were associated with low grade (G1). In this study there was a tendency to associate the age group of 60-69 years with the presence of endometrial hyperplasia and with high grade and advanced stage. Apart from the high grade and advanced stage, in the aggressive profile of the EEC can be included as the clinicopathological parameters the 7th decade of life and the irregular, MELF and MVI invasion patterns.

Keywords: Endometrial endometrioid carcinoma; invasion pattern; prognostic parameters.

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Conflict of interest statement

None to declare.

Figures

Figure 1
Figure 1
Endometrial endometrioid carcinoma (EEC), HE staining, ×100. A. Well differentiated (G1) EEC; B. Moderate differentiated (G2) EEC; Poorly differentiated (G3) EEC
Figure 2
Figure 2
Endometrial endometrioid carcinoma (EEC), HE staining, ×200. A. Squamous differentiation. B. Secretory differentiation. C. Villoglandular differentiation
Figure 3
Figure 3
Endometrial endometrioid carcinoma (EEC), invasion patterns, HE staining, x100. A. Irregular. B. Pushing. C. Diffuse infiltrative. D. Microcystic, elongated, and fragmented (MELF)
Figure 4
Figure 4
A. Distribution of cases depending on tumor stage and grade. B. Distribution of cases depending on tumor grade and invasion pattern. C. Distribution of cases depending on tumor stage and invasion pattern. D. Distribution of cases depending on age group and the presence of endometrial hyperplasia
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