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Review
. 2023 Feb;38(2):197-209.
doi: 10.1111/jgh.16046. Epub 2022 Nov 28.

Asia-Pacific guidelines for managing functional dyspepsia overlapping with other gastrointestinal symptoms

Kok-Ann Gwee  1 , Yeong Yeh Lee  2   3 , Hidekazu Suzuki  4 , Uday Chand Ghoshal  5 , Gerald Holtmann  6 , Tao Bai  7 , Giovanni Barbara  8 , Min-Hu Chen  9 , Andrew Seng Boon Chua  10 , Peter R Gibson  11 , Xiaohua Hou  7 , Jinsong Liu  7 , Atsushi Nakajima  12 , Nitesh Pratap  13 , Sanjeev Sachdeva  14 , Kewin Tien Ho Siah  15 , Alex Yu Sen Soh  15 , Kentaro Sugano  16 , Jan Tack  17 , Victoria Ping Yi Tan  18 , Xudong Tang  19 , Marjorie Walker  20 , Deng-Chyang Wu  21 , Ying-Lian Xiao  9 , Khairil Khuzaini Zulkifli  3   22 , Clarissa Toh  23
Affiliations
Review

Asia-Pacific guidelines for managing functional dyspepsia overlapping with other gastrointestinal symptoms

Kok-Ann Gwee et al. J Gastroenterol Hepatol. 2023 Feb.

Abstract

Contemporary systems for the diagnosis and management gastrointestinal symptoms not attributable to organic diseases (Functional GI Disorders, FGID, now renamed Disorders of Gut-Brain Interaction, DGBI) seek to categorize patients into narrowly defined symptom-based sub-classes to enable targeted treatment of patient cohorts with similar underlying putative pathophysiology. However, an overlap of symptom categories frequently occurs and has a negative impact on treatment outcomes. There is a lack of guidance on their management. An Asian Pacific Association of Gastroenterology (APAGE) working group was set up to develop clinical practice guidelines for management of patients with functional dyspepsia (FD) who have an overlap with another functional gastrointestinal disorder: FD with gastroesophageal reflux (FD-GERD), epigastric pain syndrome with irritable bowel syndrome (EPS-IBS), postprandial distress syndrome with IBS (PDS-IBS), and FD-Constipation. We identified putative pathophysiology to provide a basis for treatment recommendations. A management algorithm is presented to guide primary and secondary care clinicians.

Keywords: dyspepsia; epidemiology; functional; gastrointestinal; management; overlap; pathophysiology.

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References

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