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Comment
. 2022 Dec;37(12):2342.
doi: 10.1002/mds.29264. Epub 2022 Nov 2.

The Glycoprotein GPNMB: A Secret Ingredient for Understanding Parkinson's Disease Etiology?

Benjamín Matías Pizarro Galleguillos  1   2 , Wael Mohamed  3   4 , Maria Teresa Periñan  5
Affiliations
Comment

The Glycoprotein GPNMB: A Secret Ingredient for Understanding Parkinson's Disease Etiology?

Benjamín Matías Pizarro Galleguillos et al. Mov Disord. 2022 Dec.
No abstract available

Keywords: GPNMB; Parkinson's disease; α-synuclein.

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Comment on

  • GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.
    Diaz-Ortiz ME, Seo Y, Posavi M, Carceles Cordon M, Clark E, Jain N, Charan R, Gallagher MD, Unger TL, Amari N, Skrinak RT, Davila-Rivera R, Brody EM, Han N, Zack R, Van Deerlin VM, Tropea TF, Luk KC, Lee EB, Weintraub D, Chen-Plotkin AS. Diaz-Ortiz ME, et al. Science. 2022 Aug 19;377(6608):eabk0637. doi: 10.1126/science.abk0637. Epub 2022 Aug 19. Science. 2022. PMID: 35981040 Free PMC article.

References

    1. Kia DA, Zhang D, Guelfi S, et al. Identification of candidate Parkinson disease genes by integrating genome-wide association study, expression, and epigenetic data sets. JAMA Neurol 2021;78(4):464-472. https://doi.org/10.1001/jamaneurol.2020.5257
    1. Diaz-Ortiz ME, Seo Y, Posavi M, et al. GPNMB confers risk for Parkinson's disease through interaction with α-synuclein. Science 2022;377(6608):eabk0637. https://doi.org/10.1126/science.abk0637
    1. Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ. The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Neurobiol Dis 2018;120:1-11. https://doi.org/10.1016/j.nbd.2018.08.013
    1. Zhang X, Guarin D, Mohammadzadehhonarvar N, Chen X, Gao X. Parkinson's disease and cancer: a systematic review and meta-analysis of over 17 million participants. BMJ Open 2021;11:e046329. https://doi.org/10.1136/bmjopen-2020-046329

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