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. 2022 Jan;64(1):e15273.
doi: 10.1111/ped.15273.

Benign acute childhood myositis: Factors associated with muscle symptoms and resolution

Betül Öztürk  1 , Aytaç Göktuğ  1 , İlknur Bodur  1 , Raziye Merve Yaradılmış  1 , Muhammed Mustafa Güneylioğlu  1 , Ali Güngör  1 , Aysun Tekeli  2 , Ayla Akca Çağlar  3 , Can Demir Karacan  1 , Nilden Tuygun  3
Affiliations

Benign acute childhood myositis: Factors associated with muscle symptoms and resolution

Betül Öztürk et al. Pediatr Int. 2022 Jan.

Abstract

Background: Benign acute childhood myositis (BACM) is associated with several viral infections. The aim of this study was to evaluate the progression of myositis symptoms, laboratory findings and oseltamivir treatment in children with influenza- and non-influenza-associated BACM.

Methods: Patients aged 0-18 years old, admitted to the pediatric emergency department in the seasonal influenza period between 2018 and 2020 were retrospectively analyzed. Patients with acute onset calf tenderness, pain, difficulty in walking and elevated serum creatine phosphokinase were included and were grouped according to influenza rapid test kit results as influenza (A and B) positive, and influenza negative. The time to symptom resolution, laboratory data and the oseltamivir treatment were compared between the groups.

Results: There were 94 patients (67 male, 27 female) with a mean age of 77 ± 22 months. Influenza A was detected in 21, influenza B in 27, and neither were detected in 46 patients. Time to symptom resolution of BACM was shorter in the influenza-positive patients than in influenza-negative patients (2.9 ± 1.4 days and 3.5 ± 1.5 days, respectively, P = 0.027). Oseltamivir did not reduce the symptom resolution time in influenza patients. All children had normal hemoglobin and platelet counts, elevated creatine phosphokinase and 76% of them had leukopenia. Neither clinical recurrence nor metabolic disease were reported.

Conclusion: Symptoms of BACM tended to resolve slightly earlier in influenza-positive patients and the duration of symptoms was not affected by oseltamivir treatment.

Keywords: benign acute childhood myositis; creatine phosphokinase; influenza A; influenza B.

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References

    1. Ferrarini A, Lava SA, Simonetti GD, Ramelli GP, Bianchetti MG, Swiss Italian Society of Pediatrics. Influenza virus B-associated acute benign myalgia cruris: An outbreak report and review of the literature. Neuromuscul Disord. 2014; 24: 342-6.
    1. Jain S, Kolber MR. A stiff-legged gait: Benign acute childhood myositis. CMAJ 2009; 181: 711-3.
    1. Capoferri G, Milani GP, Ramelli GP, Ferrarini A, Bianchetti MG, Lava SAG. Sporadic acute benign calf myositis: Systematic literature review. Neuromuscul. Disord. 2018; 28: 443-9.
    1. Leichtenstern O. Influenza. In: Mannaberg J (ed). Malaria, Influenza and Dengue. Nothnagel's Encyclopedia of Practical Medicine. W.B. Saunders & Co, Philedelphia, 1905; 523-701.
    1. Lundberg A. Myalgia cruris epidemica. Acta Paediatr. 1957; 46: 18-31.

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