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. 2023 Mar 21;76(6):1121-1124.
doi: 10.1093/cid/ciac867.

Adverse Events Associated With Treatment for Pan-Susceptible Tuberculosis in San Francisco

Janice K Louie  1   2 , Chris Keh  2 , Rocio Agraz-Lara  1 , Allison Phillips  1 , Susannah Graves  1
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Adverse Events Associated With Treatment for Pan-Susceptible Tuberculosis in San Francisco

Janice K Louie et al. Clin Infect Dis. .

Abstract

Of 373 patients treated for drug-susceptible tuberculosis, 35.4% (46.2% aged ≥65 years) developed moderate/severe adverse events that required treatment interruption (34.8%), first-line drug discontinuation (26.2%, primarily pyrazinamide), second-line drug initiation (30.0%), and treatment duration up to 3.8 months longer. More safe and effective options are needed, including for the elderly.

Keywords: TB; adverse events; elderly; tuberculosis.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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