Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop

doi:10.1089/AID.2022.0079

. 2023 Jan;39(1):1-12.

doi: 10.1089/AID.2022.0079. Epub 2022 Nov 23.

Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop

Xiaoying Yu¹, Judith D Lobo², Erin Sundermann², Darren J Baker³, Russell P Tracy^{4

5}, George A Kuchel⁶, Kathryn E Stephenson^{7

8}, Scott L Letendre^{2

9}, Bruce Brew^{10

11

12

13}, Lucette A Cysique^{14

15

16}, Sannisha K Dale¹⁷, Chelsie Wallen¹⁷, Ken M Kunisaki^{18

19}, Giovanni Guaraldi²⁰, Jovana Milic²⁰, Alan Winston²¹, David J Moore², Joseph B Margolick²², Kristine M Erlandson^{23

24}

Affiliations

¹ Department of Biostatistics and Data Science, University of Texas Medical Branch, Galveston, Texas, USA.
² Department of Psychiatry, University of California San Diego, San Diego, California, USA.
³ Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Colchester, Vermont, USA.
⁵ Department of Biochemistry, Larner College of Medicine, University of Vermont, Colchester, Vermont, USA.
⁶ UConn Center on Aging, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
⁷ Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
⁸ Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁹ Department of Medicine, University of California San Diego, San Diego, California, USA.
¹⁰ Department of Neurology and HIV Medicine, St. Vincent's Hospital, Sydney, Australia.
¹¹ Department of Neurology, Peter Duncan Neurosciences Unit, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
¹² Faculty of Medicine, Department of Neurology, University of New South Wales Sydney, Sydney, Australia.
¹³ University of Notre Dame Australia, Sydney, Australia.
¹⁴ Faculty of Science, Department of Psychology, School of Psychology, University of New South Wales Sydney, Sydney, Australia.
¹⁵ MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
¹⁶ Neuroscience Unit, St. Vincent's Hospital Centre for Applied Medical Research, Sydney, Australia.
¹⁷ Department of Psychology, University of Miami, Coral Gables, Florida, USA.
¹⁸ Section of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.
¹⁹ Department of Medicine; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
²⁰ Department of Surgical, Medical, Dental and Morphological Sciences, Modena HIV Metabolic Clinic (MHMC), University of Modena and Reggio Emilia, Modena, Italy.
²¹ Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
²² W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
²³ Divisions of Infectious Diseases, Department of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA.
²⁴ Divisions of Geriatric Medicine, Department of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA.

PMID: 36322713
PMCID: PMC9889016
DOI: 10.1089/AID.2022.0079

Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop

Xiaoying Yu et al. AIDS Res Hum Retroviruses. 2023 Jan.

. 2023 Jan;39(1):1-12.

doi: 10.1089/AID.2022.0079. Epub 2022 Nov 23.

Authors

Affiliations

¹ Department of Biostatistics and Data Science, University of Texas Medical Branch, Galveston, Texas, USA.
² Department of Psychiatry, University of California San Diego, San Diego, California, USA.
³ Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.
⁴ Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Colchester, Vermont, USA.
⁵ Department of Biochemistry, Larner College of Medicine, University of Vermont, Colchester, Vermont, USA.
⁶ UConn Center on Aging, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
⁷ Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
⁸ Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
⁹ Department of Medicine, University of California San Diego, San Diego, California, USA.
¹⁰ Department of Neurology and HIV Medicine, St. Vincent's Hospital, Sydney, Australia.
¹¹ Department of Neurology, Peter Duncan Neurosciences Unit, St. Vincent's Centre for Applied Medical Research, Sydney, Australia.
¹² Faculty of Medicine, Department of Neurology, University of New South Wales Sydney, Sydney, Australia.
¹³ University of Notre Dame Australia, Sydney, Australia.
¹⁴ Faculty of Science, Department of Psychology, School of Psychology, University of New South Wales Sydney, Sydney, Australia.
¹⁵ MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.
¹⁶ Neuroscience Unit, St. Vincent's Hospital Centre for Applied Medical Research, Sydney, Australia.
¹⁷ Department of Psychology, University of Miami, Coral Gables, Florida, USA.
¹⁸ Section of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.
¹⁹ Department of Medicine; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
²⁰ Department of Surgical, Medical, Dental and Morphological Sciences, Modena HIV Metabolic Clinic (MHMC), University of Modena and Reggio Emilia, Modena, Italy.
²¹ Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
²² W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
²³ Divisions of Infectious Diseases, Department of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA.
²⁴ Divisions of Geriatric Medicine, Department of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, Colorado, USA.

PMID: 36322713
PMCID: PMC9889016
DOI: 10.1089/AID.2022.0079

Abstract

People with HIV on combination antiretroviral therapy (ART) have longer life expectancy and are increasingly experiencing age-related comorbidities. Thus, aging with HIV has become a central issue in clinical care and research, which has been particularly challenging with the intersection of the ongoing coronavirus (COVID)-19 pandemic. Since 2009, the International Workshop on HIV and Aging has served as a multidisciplinary platform to share research findings from cross-disciplinary fields along with community advocates to address critical issues in HIV and aging. In this article, we summarize the key oral presentations from the 12th Annual International Workshop on HIV and Aging, held virtually on September 23rd and 24^th, 2021. The topics ranged from basic science research on biological mechanisms of aging to quality of life and delivery of care under the COVID-19 pandemic. This workshop enriched our understanding of HIV and aging under the COVID-19 pandemic, identified challenges and opportunities to combat the impact of COVID-19 on HIV communities, and also provided updated research and future directions of the field to move HIV and aging research forward, with the ultimate goal of successful aging for older people with HIV.

Keywords: COVID-19; HIV; aging; biological mechanism; delivery of care; quality of life.

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Conflict of interest statement

D.J.B. is a co-inventor on patent applications licensed to or filed by Unity Biotechnology, a company developing senolytic strategies for treatment of age-related disorders, including small molecules that selectively eliminate senescent cells. Research in the Baker laboratory has been reviewed by the Mayo Clinic Conflict of Interest Review Board and is being conducted in compliance with Mayo Clinic Conflict of Interest policies. G.A.K. has served as consultant for Spring Discovery, resTORbio, and Janssen Pharmaceuticals. K.M.K. reports personal fees from Nuvaira (Data Safety and Monitoring Board co-chair) and Allergan (consulting).

G.G. received research grant and speaker honorarium from Gilead, ViiV, MERCK, and Jansen. G.G. attended advisory boards of Gilead, ViiV, and MERCK. A.W. has received speaker honoraria or grants to Imperial College London on behalf of Gilead Sciences, ViiV Health care, Janssen, and MSD. K.M.E. reports research funding from Gilead Sciences, and consulting payments from Gilead Sciences, Janssen Pharmaceuticals, and ViiV Pharmaceuticals (all paid to the University of Colorado).

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References

1. Autenrieth CS, Beck EJ, Stelzle D, et al. . Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000–2020. PLoS One 2018;13(11):e0207005. - PMC - PubMed
1. Centers for Disease Control and Prevention. HIV Surveillance Report, 2019; vol. 32. Published May 2021. Available from: https://www.cdc.gov/hiv/library/reports/hiv-surveillance.html [Last accessed: November 2, 2021].
1. Smit M, Brinkman K, Geerlings S, et al. . Future challenges for clinical care of an ageing population infected with HIV: A modelling study. Lancet Infect Dis 2015;15(7):810–818. - PMC - PubMed
1. Kamkwalala AR, Garg A, Roy U, et al. . Current considerations for clinical management and care of people with HIV: Findings from the 11th Annual International HIV and Aging Workshop. AIDS Res Hum Retroviruses 2021;37(11):807–820. - PMC - PubMed
1. Nguyen AL, Davtyan M, Taylor J, et al. . Living with HIV during the COVID-19 pandemic: Impacts for older adults in Palm Springs, California. AIDS Educ Prev 2021;33(4):265–275. - PMC - PubMed

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[1] Autenrieth CS, Beck EJ, Stelzle D, et al. . Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000–2020. PLoS One 2018;13(11):e0207005. - PMC - PubMed

[2] Autenrieth CS, Beck EJ, Stelzle D, et al. . Global and regional trends of people living with HIV aged 50 and over: Estimates and projections for 2000–2020. PLoS One 2018;13(11):e0207005. - PMC - PubMed

[3] Centers for Disease Control and Prevention. HIV Surveillance Report, 2019; vol. 32. Published May 2021. Available from: https://www.cdc.gov/hiv/library/reports/hiv-surveillance.html [Last accessed: November 2, 2021].

[4] Centers for Disease Control and Prevention. HIV Surveillance Report, 2019; vol. 32. Published May 2021. Available from: https://www.cdc.gov/hiv/library/reports/hiv-surveillance.html [Last accessed: November 2, 2021].

[5] Smit M, Brinkman K, Geerlings S, et al. . Future challenges for clinical care of an ageing population infected with HIV: A modelling study. Lancet Infect Dis 2015;15(7):810–818. - PMC - PubMed

[6] Smit M, Brinkman K, Geerlings S, et al. . Future challenges for clinical care of an ageing population infected with HIV: A modelling study. Lancet Infect Dis 2015;15(7):810–818. - PMC - PubMed

[7] Kamkwalala AR, Garg A, Roy U, et al. . Current considerations for clinical management and care of people with HIV: Findings from the 11th Annual International HIV and Aging Workshop. AIDS Res Hum Retroviruses 2021;37(11):807–820. - PMC - PubMed

[8] Kamkwalala AR, Garg A, Roy U, et al. . Current considerations for clinical management and care of people with HIV: Findings from the 11th Annual International HIV and Aging Workshop. AIDS Res Hum Retroviruses 2021;37(11):807–820. - PMC - PubMed

[9] Nguyen AL, Davtyan M, Taylor J, et al. . Living with HIV during the COVID-19 pandemic: Impacts for older adults in Palm Springs, California. AIDS Educ Prev 2021;33(4):265–275. - PMC - PubMed

[10] Nguyen AL, Davtyan M, Taylor J, et al. . Living with HIV during the COVID-19 pandemic: Impacts for older adults in Palm Springs, California. AIDS Educ Prev 2021;33(4):265–275. - PMC - PubMed

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Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop

Affiliations

Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop

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Affiliations

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Conflict of interest statement

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