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Comment
. 2022 Nov 1;34(11):1615-1616.
doi: 10.1016/j.cmet.2022.10.004.

An emerging direction in glucagon-based therapy

Yan Chen  1 , Dehua Yang  2 , Ming-Wei Wang  3
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An emerging direction in glucagon-based therapy

Yan Chen et al. Cell Metab. .
Free article

Abstract

Glucagon receptor (GCGR) is an essential regulator of hepatic metabolism. In this issue of Cell Metabolism, Sekar et al. report that the endosomal protein Vps37a uncouples hepatic glucose production from lipid metabolism by altering the intracellular localization of GCGR, thereby providing a new potential therapeutic direction for type 2 diabetes.

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Declaration of interests The authors declare no conflicts of interest.

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