Radiological endpoints as surrogates for survival benefit in hepatocellular carcinoma trials: All that glitters is not gold

Giuseppe Cabibbo¹, Jordi Bruix²

Affiliations

¹ Section of Gastroenterology and Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo, Palermo, Italy. Electronic address: giuseppe.cabibbo@unipa.it.
² BCLC Group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBEREHD, University of Barcelona, Barcelona, Spain. Electronic address: jbruix@clinical.cat.

PMID: 36323356
DOI: 10.1016/j.jhep.2022.10.018

Editorial

Radiological endpoints as surrogates for survival benefit in hepatocellular carcinoma trials: All that glitters is not gold

Giuseppe Cabibbo et al. J Hepatol. 2023 Jan.

. 2023 Jan;78(1):8-11.

doi: 10.1016/j.jhep.2022.10.018. Epub 2022 Oct 30.

Authors

Giuseppe Cabibbo¹, Jordi Bruix²

Affiliations

¹ Section of Gastroenterology and Hepatology, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties PROMISE, University of Palermo, Palermo, Italy. Electronic address: giuseppe.cabibbo@unipa.it.
² BCLC Group, Liver Unit, Hospital Clinic Barcelona, IDIBAPS, CIBEREHD, University of Barcelona, Barcelona, Spain. Electronic address: jbruix@clinical.cat.

PMID: 36323356
DOI: 10.1016/j.jhep.2022.10.018

No abstract available

Keywords: Immune Checkpoint Inhibitors; Liver cancer; competing risk; objective response; overall survival; prognosis; progression free survival; surrogacy; tyrosine kinase inhibitors.

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Overall survival and objective response in advanced unresectable hepatocellular carcinoma: A subanalysis of the REFLECT study.
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Vogel A, Tovoli F, Ueshima K, Aikata H, López CL, Pracht M, Meng Z, Daniele B, Park JW, Palmer D, Tamai T, Saito K, Dutcus CE, Lencioni R. Kudo M, et al. J Hepatol. 2023 Jan;78(1):133-141. doi: 10.1016/j.jhep.2022.09.006. Epub 2022 Sep 20. J Hepatol. 2023. PMID: 36341767 Clinical Trial.

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Radiological endpoints as surrogates for survival benefit in hepatocellular carcinoma trials: All that glitters is not gold

Affiliations

Radiological endpoints as surrogates for survival benefit in hepatocellular carcinoma trials: All that glitters is not gold

Authors

Affiliations

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Medical