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Meta-Analysis
. 2022 Nov 2;21(1):226.
doi: 10.1186/s12933-022-01664-9.

Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Feifei Yan #  1 , Shoumeng Yan #  2 , Jing Wang  1 , Yani Cui  1 , Feinan Chen  1 , Fang Fang  3 , Weiwei Cui  4
Affiliations
Meta-Analysis

Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Feifei Yan et al. Cardiovasc Diabetol. .

Abstract

Background: The triglyceride glucose (TyG) index, which is a new surrogate indicator of insulin resistance (IR), is thought to be associated with many diseases, such as cardiovascular disease, but its relationship with cerebrovascular disease is still controversial.

Methods: The PubMed, EMBASE, Cochrane Library, Web of Science and Medline databases were searched until March 2022 to evaluate the association between the TyG index and cerebrovascular disease risk. A random‒effects model was used to calculate the effect estimates and 95% confidence intervals (CIs).

Results: A total of 19 cohort studies and 10 case‒control/cross‒sectional studies were included in our study, which included 11,944,688 participants. Compared with a low TyG index, a higher TyG index increased the risk of cerebrovascular disease (RR/HR = 1.22, 95% CI [1.14, 1.30], P< 0.001; OR = 1.15, 95% CI [1.07, 1.23], P< 0.001). Furthermore, the results of the dose-response analysis of the cohort study demonstrated that the risk of cerebrovascular disease increased by 1.19 times per 1 mg/dl increment of the TyG index (relative risk = 1.19, 95% CI [1.13,1.25], P< 0.001).

Conclusion: TyG index is related to cerebrovascular disease. More data and basic research are needed to confirm the association.

Keywords: Cerebrovascular disease; Dose‒response relationship; Observational research; Triglyceride glucose index; meta‒analysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Flow diagram of the literature search and selection
Fig. 2
Fig. 2
Forest plot of the risk of cerebrovascular disease in subjects with a high TyG index vs. a low TyG index (cohort studies; RR/HR, relative risk/hazard ratio; CI, confidence interval)
Fig. 3
Fig. 3
Funnel plot for the effect estimates of the TyG index (cohort studies; ln RR/HR = ln (relative risk/hazard ratio); se, standard error)
Fig. 4
Fig. 4
Dose-response plot of the TyG index and cerebrovascular disease (restricted cubic spline random effects model; bold dotted line, 95% confidence intervals for splines)
Fig. 5
Fig. 5
Forest plot of the risk of cerebrovascular disease in populations with a high TyG index vs. control groups (case-control/cross-sectional studies; OR, odds ratio; CI, confidence interval)
Fig. 6
Fig. 6
Funnel plot for the effect estimates of the TyG index (case-control/cross-sectional studies; lnOR = ln(odds ratio); se, standard error)
See this image and copyright information in PMC

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