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Comment
. 2022 Oct 17:9:1012452.
doi: 10.3389/fcvm.2022.1012452. eCollection 2022.

Commentary: Plasma angiotensin II is increased in critical coronavirus disease 2019

Dirk van Lier  1 , Matthijs Kox  1 , Peter Pickkers  1
Affiliations
Comment

Commentary: Plasma angiotensin II is increased in critical coronavirus disease 2019

Dirk van Lier et al. Front Cardiovasc Med. .
No abstract available

Keywords: COVID-19; angiotensin converting enzyme; enzyme-linked immunosorbent assay (ELISA); liquid chromatography–mass spectrometry; renin angiotensin aldosterone system.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Overview of angiotensin metabolite measurements in COVID-19 patients and healthy volunteers in different studies. ELISA, enzyme-linked immunoassay; LC-MS, liquid chromatography–mass spectrometry; LC-MS equilibrium, measurement method without protein inhibitor cocktail, that assesses RAAS enzymes in the circulatory compartment; LC-MS with inhibitor cocktail, measurement method that assesses true circulating levels of metabolites by direct inhibition of enzymes during sample withdrawal; Ang-1–7/Ang-II-ratio, Angiotensin-1-7 Angiotensin-II ratio. *Exact levels of angiotensin metabolites were not reported by Camargo et al., and were thus inferred from the figures.
See this image and copyright information in PMC

Comment on

  • Plasma Angiotensin II Is Increased in Critical Coronavirus Disease 2019.
    Camargo RL, Bombassaro B, Monfort-Pires M, Mansour E, Palma AC, Ribeiro LC, Ulaf RG, Bernardes AF, Nunes TA, Agrela MV, Dertkigil RP, Dertkigil SS, Araujo EP, Nadruz W, Moretti ML, Velloso LA, Sposito AC. Camargo RL, et al. Front Cardiovasc Med. 2022 Jun 24;9:847809. doi: 10.3389/fcvm.2022.847809. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35811697 Free PMC article.

References

    1. Camargo RL, Bombassaro B, Monfort-Pires M, Mansour E, Palma AC, Ribeiro LC, et al. . Plasma angiotensin II is increased in critical coronavirus disease 2019. Front Cardiovasc Med. (2022) 9:847809. 10.3389/fcvm.2022.847809 - DOI - PMC - PubMed
    1. Paz Ocaranza M, Riquelme JA, Garcia L, Jalil JE, Chiong M, Santos RAS, et al. . Counter-regulatory renin-angiotensin system in cardiovascular disease. Nat Rev Cardiol. (2020) 17:116–29. 10.1038/s41569-019-0244-8 - DOI - PMC - PubMed
    1. Chappell MC. Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute? Am J Physiol Heart Circ Physiol. (2016) 310:H137–52. 10.1152/ajpheart.00618.2015 - DOI - PMC - PubMed
    1. Chappell MC, Pirro NT, South AM, Gwathmey TM. Concerns on the specificity of commercial ELISAs for the measurement of angiotensin (1-7) and angiotensin II in human plasma. Hypertension. (2021) 77:e29–31. 10.1161/HYPERTENSIONAHA.120.16724 - DOI - PMC - PubMed
    1. Poglitsch M, Sturrock ED, Danser AH. Letter to the editor: angiotensin quantification by mass spectrometry. Am J Physiol Heart Circ Physiol. (2016) 310:H452–3. 10.1152/ajpheart.00933.2015 - DOI - PubMed

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