Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study

Bernardo Sousa-Pinto^{1

2

3}, Holger J Schünemann⁴, Ana Sá-Sousa^{1

2

3}, Rafael José Vieira^{1

2

3}, Rita Amaral^{1

2

3}, Josep M Anto^{5

6

7

8}, Ludger Klimek^{9

10}, Wienczyslawa Czarlewski¹¹, Joaquim Mullol¹², Oliver Pfaar¹³, Anna Bedbrook¹⁴, Luisa Brussino¹⁵, Violeta Kvedariene^{16

17}, Désirée E Larenas-Linnemann¹⁸, Yoshitaka Okamoto¹⁹, Maria Teresa Ventura²⁰, Ioana Agache²¹, Ignacio J Ansotegui²², Karl C Bergmann^{23

24}, Sinthia Bosnic-Anticevich²⁵, G Walter Canonica^{26

27}, Victoria Cardona²⁸, Pedro Carreiro-Martins^{29

30}, Thomas Casale³¹, Lorenzo Cecchi³², Tomas Chivato³³, Derek K Chu⁴, Cemal Cingi³⁴, Elísio M Costa³⁵, Alvaro A Cruz³⁶, Stefano Del Giacco³⁷, Philippe Devillier³⁸, Patrik Eklund³⁹, Wytske J Fokkens⁴⁰, Bilun Gemicioglu⁴¹, Tari Haahtela⁴², Juan Carlos Ivancevich⁴³, Zhanat Ispayeva⁴⁴, Marek Jutel⁴⁵, Piotr Kuna⁴⁶, Igor Kaidashev⁴⁷, Musa Khaitov^{48

49}, Helga Kraxner⁵⁰, Daniel Laune⁵¹, Brian Lipworth⁵², Renaud Louis⁵³, Michael Makris⁵⁴, Riccardo Monti⁵⁵, Mario Morais-Almeida⁵⁶, Ralph Mösges⁵⁷, Marek Niedoszytko⁵⁸, Nikolaos G Papadopoulos⁵⁹, Vincenzo Patella⁶⁰, Nhân Pham-Thi⁶¹, Frederico S Regateiro^{62

63

64}, Sietze Reitsma⁶⁵, Philip W Rouadi^{66

67}, Boleslaw Samolinski⁶⁸, Aziz Sheikh⁶⁹, Milan Sova⁷⁰, Ana Todo-Bom⁷¹, Luis Taborda-Barata^{72

73

74}, Sanna Toppila-Salmi⁴², Joaquin Sastre⁷⁵, Ioanna Tsiligianni^{76

77}, Arunas Valiulis⁷⁸, Olivier Vandenplas⁷⁹, Dana Wallace⁸⁰, Susan Waserman⁸¹, Arzu Yorgancioglu⁸², Mihaela Zidarn^{83

84}, Torsten Zuberbier^{23

24}, Joao A Fonseca^{1

2

3}, Jean Bousquet^{23

24

85}

Affiliations

¹ MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
² CINTESIS - Center for Health Technology and Services Research, University of Porto, Porto, Portugal.
³ RISE - Health Research Network, University of Porto, Porto, Portugal.
⁴ Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
⁵ ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
⁶ IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
⁷ Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
⁹ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
¹⁰ Center for Rhinology and Allergology, Wiesbaden, Germany.
¹¹ Medical Consulting Czarlewski, Levallois, France.
¹² Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
¹³ Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
¹⁴ ARIA, Montpellier, France.
¹⁵ Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy.
¹⁶ Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁷ Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁸ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
¹⁹ Chiba University Hospital and Chiba Rosai Hospital, Chiba, Japan.
²⁰ Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
²¹ Transylvania University Brasov, Brasov, Romania.
²² Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
²³ Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²⁴ Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
²⁵ Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney and Sydney Local Health District, Sydney, New South Wales, Australia.
²⁶ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
²⁷ Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
²⁸ Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL research network, Barcelona, Spain.
²⁹ Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
³⁰ NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal.
³¹ Division of Allergy/immunology, University of South Florida, Tampa, Florida, USA.
³² SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
³³ School of Medicine, University CEU San Pablo, Madrid, Spain.
³⁴ ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
³⁵ UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.
³⁶ Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil.
³⁷ Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.
³⁸ VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
³⁹ Department of Computing Science, Umeå University, Umeå, Sweden.
⁴⁰ Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.
⁴¹ Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
⁴² Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
⁴³ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
⁴⁴ Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.
⁴⁵ Department of Clinical Immunology, Wrocław Medical University, and ALL-MED Medical Research Institute, Wroclaw, Poland.
⁴⁶ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
⁴⁷ Poltava State Medical University, Poltava, Ukraine.
⁴⁸ Laboratory of Molecular immunology, National Research Center, Institute of Immunology, Federal Medicobiological Agency, Moscow, Russian Federation.
⁴⁹ Pirogov Russian National Research Medical University, Moscow, Russian Federation.
⁵⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
⁵¹ KYomed INNOV, Montpellier, France.
⁵² Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.
⁵³ Department of Pulmonary Medicine, CHU Liège and GIGA I3 research group, University of Liège, Liege, Belgium.
⁵⁴ Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, "Attikon" University Hospital, National & Kapodistrian University of Athens, Athens, Greece.
⁵⁵ Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
⁵⁶ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
⁵⁷ IMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH, Cologne, Germany.
⁵⁸ Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.
⁵⁹ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁶⁰ Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia and Agency of Health ASL, Salerno, Italy.
⁶¹ Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France.
⁶² Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
⁶³ Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
⁶⁴ Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.
⁶⁵ Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, The Netherlands.
⁶⁶ Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
⁶⁷ Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait.
⁶⁸ Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
⁶⁹ Usher Institute, The University of Edinburgh, Edinburgh, UK.
⁷⁰ Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic.
⁷¹ Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
⁷² CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
⁷³ UBIAir - Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal.
⁷⁴ Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
⁷⁵ Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain.
⁷⁶ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Iraklio, Greece.
⁷⁷ International Primary Care Respiratory Group IPCRG, Aberdeen, UK.
⁷⁸ Institute of Clinical Medicine and Institute of Health Sciences, Vilnius and Medical Faculty of Vilnius University, Vilnius, Lithuania.
⁷⁹ Department of Chest Medicine, Centre Hospitalier Universitaire UCL, Namur, and Université Catholique de Louvain, Yvoir, Belgium.
⁸⁰ Nova Southeastern University, Fort Lauderdale, Florida, USA.
⁸¹ Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
⁸² Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
⁸³ University Clinic of Respiratory and Allergic Diseases, Golnick, Slovenia.
⁸⁴ Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
⁸⁵ University Hospital Montpellier, Montpellier, France.

PMID: 36325824
DOI: 10.1111/all.15574

Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study

Bernardo Sousa-Pinto et al. Allergy. 2023 Apr.

. 2023 Apr;78(4):968-983.

doi: 10.1111/all.15574. Epub 2022 Nov 20.

Authors

Affiliations

¹ MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
² CINTESIS - Center for Health Technology and Services Research, University of Porto, Porto, Portugal.
³ RISE - Health Research Network, University of Porto, Porto, Portugal.
⁴ Department of Health Research Methods, Evidence, and Impact & Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
⁵ ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
⁶ IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
⁷ Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
⁹ Department of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
¹⁰ Center for Rhinology and Allergology, Wiesbaden, Germany.
¹¹ Medical Consulting Czarlewski, Levallois, France.
¹² Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.
¹³ Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
¹⁴ ARIA, Montpellier, France.
¹⁵ Department of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy.
¹⁶ Institute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁷ Institute of Clinical medicine, Clinic of Chest diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
¹⁸ Center of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
¹⁹ Chiba University Hospital and Chiba Rosai Hospital, Chiba, Japan.
²⁰ Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.
²¹ Transylvania University Brasov, Brasov, Romania.
²² Department of Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
²³ Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²⁴ Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany.
²⁵ Quality Use of Respiratory Medicine Group, Woolcock Institute of Medical Research, The University of Sydney and Sydney Local Health District, Sydney, New South Wales, Australia.
²⁶ Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
²⁷ Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Rozzano, Italy.
²⁸ Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL research network, Barcelona, Spain.
²⁹ Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
³⁰ NOVA Medical School/Comprehensive Health Research Centre (CHRC), Lisbon, Portugal.
³¹ Division of Allergy/immunology, University of South Florida, Tampa, Florida, USA.
³² SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
³³ School of Medicine, University CEU San Pablo, Madrid, Spain.
³⁴ ENT Department, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
³⁵ UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.
³⁶ Fundaçao ProAR, Federal University of Bahia and GARD/WHO Planning Group, Salvador, Brazil.
³⁷ Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology, University Hospital "Duilio Casula", University of Cagliari, Cagliari, Italy.
³⁸ VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
³⁹ Department of Computing Science, Umeå University, Umeå, Sweden.
⁴⁰ Department of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.
⁴¹ Department of Pulmonary Diseases, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
⁴² Skin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
⁴³ Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
⁴⁴ Kazakhstan Association of Allergology and Clinical Immunology, Department of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.
⁴⁵ Department of Clinical Immunology, Wrocław Medical University, and ALL-MED Medical Research Institute, Wroclaw, Poland.
⁴⁶ Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
⁴⁷ Poltava State Medical University, Poltava, Ukraine.
⁴⁸ Laboratory of Molecular immunology, National Research Center, Institute of Immunology, Federal Medicobiological Agency, Moscow, Russian Federation.
⁴⁹ Pirogov Russian National Research Medical University, Moscow, Russian Federation.
⁵⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
⁵¹ KYomed INNOV, Montpellier, France.
⁵² Scottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.
⁵³ Department of Pulmonary Medicine, CHU Liège and GIGA I3 research group, University of Liège, Liege, Belgium.
⁵⁴ Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, "Attikon" University Hospital, National & Kapodistrian University of Athens, Athens, Greece.
⁵⁵ Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
⁵⁶ Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
⁵⁷ IMSB, Medical Faculty, University at Cologne, and ClinCompetence Cologne GmbH, Cologne, Germany.
⁵⁸ Department of Allergology, Medical University of Gdańsk, Gdansk, Poland.
⁵⁹ Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
⁶⁰ Division of Allergy and Clinical Immunology, Department of Medicine, "Santa Maria della Speranza" Hospital, Battipaglia and Agency of Health ASL, Salerno, Italy.
⁶¹ Ecole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France.
⁶² Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
⁶³ Faculty of Medicine, Institute of Immunology, University of Coimbra, Coimbra, Portugal.
⁶⁴ Faculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Coimbra, Portugal.
⁶⁵ Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, The Netherlands.
⁶⁶ Department of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
⁶⁷ Department of Otorhinolaryngology-Head and Neck Surgery, Dar Al Shifa Hospital, Salmiya, Kuwait.
⁶⁸ Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
⁶⁹ Usher Institute, The University of Edinburgh, Edinburgh, UK.
⁷⁰ Department of Respiratory Medicine and Tuberculosis, University Hospital, Brno, Czech Republic.
⁷¹ Imunoalergologia, Centro Hospitalar Universitário de Coimbra, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
⁷² CICS-UBI Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
⁷³ UBIAir - Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal.
⁷⁴ Department of Immunoallergology, Cova da Beira University Hospital Centre, Covilhã, Portugal.
⁷⁵ Fundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain.
⁷⁶ Health Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Iraklio, Greece.
⁷⁷ International Primary Care Respiratory Group IPCRG, Aberdeen, UK.
⁷⁸ Institute of Clinical Medicine and Institute of Health Sciences, Vilnius and Medical Faculty of Vilnius University, Vilnius, Lithuania.
⁷⁹ Department of Chest Medicine, Centre Hospitalier Universitaire UCL, Namur, and Université Catholique de Louvain, Yvoir, Belgium.
⁸⁰ Nova Southeastern University, Fort Lauderdale, Florida, USA.
⁸¹ Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
⁸² Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa, Turkey.
⁸³ University Clinic of Respiratory and Allergic Diseases, Golnick, Slovenia.
⁸⁴ Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
⁸⁵ University Hospital Montpellier, Montpellier, France.

PMID: 36325824
DOI: 10.1111/all.15574

Abstract

Introduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air® longitudinally, clustering weeks according to reported rhinitis symptoms.

Methods: We analyzed MASK-air® data, assessing the weeks for which patients had answered a rhinitis daily questionnaire on all 7 days. We firstly used k-means clustering algorithms for longitudinal data to define clusters of weeks according to the trajectories of reported daily rhinitis symptoms. Clustering was applied separately for weeks when medication was reported or not. We compared obtained clusters on symptoms and rhinitis medication patterns. We then used the latent class mixture model to assess the robustness of results.

Results: We analyzed 113,239 days (16,177 complete weeks) from 2590 patients (mean age ± SD = 39.1 ± 13.7 years). The first clustering algorithm identified ten clusters among weeks with medication use: seven with low variability in rhinitis control during the week and three with highly-variable control. Clusters with poorly-controlled rhinitis displayed a higher frequency of rhinitis co-medication, a more frequent change of medication schemes and more pronounced seasonal patterns. Six clusters were identified in weeks when no rhinitis medication was used, displaying similar control patterns. The second clustering method provided similar results. Moreover, patients displayed consistent levels of rhinitis control, reporting several weeks with similar levels of control.

Conclusions: We identified 16 patterns of weekly rhinitis control. Co-medication and medication change schemes were common in uncontrolled weeks, reinforcing the hypothesis that patients treat themselves according to their symptoms.

Keywords: mobile health; patient-reported outcomes; real-world data; rhinitis.

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References

REFERENCES

1. Bousquet J, Bedbrook A, Czarlewski W, et al. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma. Clin Transl Allergy. 2019;9:16.
1. Bousquet J, Anto JM, Bachert C, et al. From ARIA guidelines to the digital transformation of health in rhinitis and asthma multimorbidity. Eur Respir J. 2019;54(6):1901023.
1. Bousquet J, Bewick M, Arnavielhe S, et al. Work productivity in rhinitis using cell phones: the MASK pilot study. Allergy. 2017;72(10):1475-1484.
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Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study

Affiliations

Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The MASK-air® longitudinal study

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical