Multicenter Study

. 2022 Nov 2;6(6):zrac128.

doi: 10.1093/bjsopen/zrac128.

Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry

Lea Valeska Blum¹, Elke Schmitt^{1

2}, Suma Choorapoikayil¹, Olaf Baumhove³, Alexandra Bayer⁴, Patrick Friederich⁵, Jens Friedrich⁶, Christof Geisen⁷, Matthias Gruenewald⁸, Martin Gutjahr⁹, Eva Herrmann², Markus Müller⁷, Diana Narita¹⁰, Ansgar Raadts¹¹, Klaus Schwendner¹², Erhard Seifried⁷, Patrick Stark¹³, Josef Thoma¹⁴, Henry Weigt¹⁵, Christoph Wiesenack¹⁶, Andrea Ulrike Steinbicker^{1

17}, Kai Zacharowski¹, Patrick Meybohm^{1

18}; German PBM Network Collaborators

Collaborators, Affiliations

Collaborators

German PBM Network Collaborators:
O Baumhove, S de Leeuw van Weenen, D Narita, J M Huber, E Adam, S Choorapoikayil, L Hof, S Isik, M Krämer, H Neb, V Neef, F Piekarski, E Schmitt, K Zacharowski, T Walther, T Holubec, A Schnitzbauer, W O Bechstein, W Derwich, T Schmitz-Rixen, B Steffen, H Serve, J Bojunga, S Zeuzem, J Konczalla, V Seifert, F Roos, F Chun, C Nau, I Marzi, M Leinung, T Stöver, S Ghanaati, R Sader, F Louwen, S Becker, J Ernst, Joachim Sauter, C Wiesenack, M Gerber, A Bayer, H Weigt, A Raadts, J Duemmler, M Gruenewald, Lars Hummitzsch, U Lorenzen, J Renner, M Sokirjanski, M Steinfath, M Pagel, A Haneya, T Puehler, R Berndt, R Rusch, T Becker, J Pochhammer, T Klueter, A Seekamp, H Ahmeti, A Helmers, Daniar Osmonow, Dirk Bauerschlag, Henning Wieker, Markus Hoffmann, J Friedrich, Gerd Molter, M Bier, M Gutjahr, R Bauer, B Bräutigam, P Friederich, H K Van Aken, A Boanta, J Becker, M Bomert, A Bueckmann, K Boerner, A Ceanga, M Nunez Cortés, I Duran, T Fraune, R Gallaby, D Goncalves, Ml Heßler, M Hawari, D J Jenke, K Kieserling, J Korhonen, J Krycki, F Lehmann, T Maeßen, V Mocanu, Pk Naber, Sn Opas, F Peters, M Rauer, H Rieder, R Van Ohlen, B Schilling, D Scholle, J Schulz, D Schwellenbach, A U Steinbicker, I Thoene, A Ueding, G Varelas, L Warnken, C Wempe, I Wisudanto, A Zarbock, N Zurheiden, W Stummer, B Brokinkel, S Martens, N Senniger, H Wolters, A Pascher, G Gosheger, B Moellenbeck, N Deventer, A Oberhuber, B Kasprzak, E Herrmann, A Schrader, L Kiesel, J Kleinheinz, C Koesters, M J Raschke, T Latal, D Niehoff, R G Geissler, H Hillmann, M Stelljes, A Kerkhoff, W Berdel, G Lenz, K Schwendner, J Thoma, P Helmer, S Hottenrott, P Kranke, P Meybohm, D Roeder, T Schlesinger, M Sitter, J Stumpner, P Stark

Affiliations

¹ Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
² Department of Medicine, Institute of Biostatistics and Mathematical Modelling, Goethe University, Frankfurt, Germany.
³ Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Klinikum Westmuensterland, Bocholt, Germany.
⁴ Department of Anaesthesiology and Intensive Care Medicine, Agatharied Hospital, Hausham, Germany.
⁵ Department of Anaesthesiology, Operative Intensive Care Medicine and Pain Therapy, Munich, Germany.
⁶ Department of Anaesthesiology and Intensive Care Medicine, Klinikum Leverkusen, Leverkusen, Germany.
⁷ German Red Cross, Institute for Transfusion Medicine and Immunohaematology, German Red Cross Baden-Wuertemberg-Hessen, Goethe University Frankfurt, Frankfurt am Main, Germany.
⁸ Department of Anaesthesiology and Operative Intensive Care Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.
⁹ Department of Anaesthesiology, Marienhaus, Ottweiler, Germany.
¹⁰ Institute for Laboratory Diagnostics and Transfusion Medicine, Donauisarklinikum, Deggendorf, Germany.
¹¹ Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany.
¹² Department of Anaesthesiology and Operative Intensive Care Medicine, Diakonie Hospital Martha-Maria, Nuremberg, Germany.
¹³ Department of Visceral and Vascular Surgery, Klinikum Mittelmosel, Zell, Germany.
¹⁴ Department of Anaesthesiology and Operative Intensive Care Medicine, Ortenauklinikum, Gengenbach, Germany.
¹⁵ Department of Anaesthesiology, SLK-Kliniken, Heilbronn, Germany.
¹⁶ Department of Anaesthesiology, Evangelisches Diakoniekrankenhaus Freiburg, Freiburg, Germany.
¹⁷ Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany.
¹⁸ Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

PMID: 36326235
PMCID: PMC9631974
DOI: 10.1093/bjsopen/zrac128

Multicenter Study

Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry

Lea Valeska Blum et al. BJS Open. 2022.

. 2022 Nov 2;6(6):zrac128.

doi: 10.1093/bjsopen/zrac128.

Authors

Collaborators

German PBM Network Collaborators:
O Baumhove, S de Leeuw van Weenen, D Narita, J M Huber, E Adam, S Choorapoikayil, L Hof, S Isik, M Krämer, H Neb, V Neef, F Piekarski, E Schmitt, K Zacharowski, T Walther, T Holubec, A Schnitzbauer, W O Bechstein, W Derwich, T Schmitz-Rixen, B Steffen, H Serve, J Bojunga, S Zeuzem, J Konczalla, V Seifert, F Roos, F Chun, C Nau, I Marzi, M Leinung, T Stöver, S Ghanaati, R Sader, F Louwen, S Becker, J Ernst, Joachim Sauter, C Wiesenack, M Gerber, A Bayer, H Weigt, A Raadts, J Duemmler, M Gruenewald, Lars Hummitzsch, U Lorenzen, J Renner, M Sokirjanski, M Steinfath, M Pagel, A Haneya, T Puehler, R Berndt, R Rusch, T Becker, J Pochhammer, T Klueter, A Seekamp, H Ahmeti, A Helmers, Daniar Osmonow, Dirk Bauerschlag, Henning Wieker, Markus Hoffmann, J Friedrich, Gerd Molter, M Bier, M Gutjahr, R Bauer, B Bräutigam, P Friederich, H K Van Aken, A Boanta, J Becker, M Bomert, A Bueckmann, K Boerner, A Ceanga, M Nunez Cortés, I Duran, T Fraune, R Gallaby, D Goncalves, Ml Heßler, M Hawari, D J Jenke, K Kieserling, J Korhonen, J Krycki, F Lehmann, T Maeßen, V Mocanu, Pk Naber, Sn Opas, F Peters, M Rauer, H Rieder, R Van Ohlen, B Schilling, D Scholle, J Schulz, D Schwellenbach, A U Steinbicker, I Thoene, A Ueding, G Varelas, L Warnken, C Wempe, I Wisudanto, A Zarbock, N Zurheiden, W Stummer, B Brokinkel, S Martens, N Senniger, H Wolters, A Pascher, G Gosheger, B Moellenbeck, N Deventer, A Oberhuber, B Kasprzak, E Herrmann, A Schrader, L Kiesel, J Kleinheinz, C Koesters, M J Raschke, T Latal, D Niehoff, R G Geissler, H Hillmann, M Stelljes, A Kerkhoff, W Berdel, G Lenz, K Schwendner, J Thoma, P Helmer, S Hottenrott, P Kranke, P Meybohm, D Roeder, T Schlesinger, M Sitter, J Stumpner, P Stark

Affiliations

¹ Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
² Department of Medicine, Institute of Biostatistics and Mathematical Modelling, Goethe University, Frankfurt, Germany.
³ Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Klinikum Westmuensterland, Bocholt, Germany.
⁴ Department of Anaesthesiology and Intensive Care Medicine, Agatharied Hospital, Hausham, Germany.
⁵ Department of Anaesthesiology, Operative Intensive Care Medicine and Pain Therapy, Munich, Germany.
⁶ Department of Anaesthesiology and Intensive Care Medicine, Klinikum Leverkusen, Leverkusen, Germany.
⁷ German Red Cross, Institute for Transfusion Medicine and Immunohaematology, German Red Cross Baden-Wuertemberg-Hessen, Goethe University Frankfurt, Frankfurt am Main, Germany.
⁸ Department of Anaesthesiology and Operative Intensive Care Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.
⁹ Department of Anaesthesiology, Marienhaus, Ottweiler, Germany.
¹⁰ Institute for Laboratory Diagnostics and Transfusion Medicine, Donauisarklinikum, Deggendorf, Germany.
¹¹ Department of Anaesthesiology and Intensive Care Medicine, University Hospital Jena, Jena, Germany.
¹² Department of Anaesthesiology and Operative Intensive Care Medicine, Diakonie Hospital Martha-Maria, Nuremberg, Germany.
¹³ Department of Visceral and Vascular Surgery, Klinikum Mittelmosel, Zell, Germany.
¹⁴ Department of Anaesthesiology and Operative Intensive Care Medicine, Ortenauklinikum, Gengenbach, Germany.
¹⁵ Department of Anaesthesiology, SLK-Kliniken, Heilbronn, Germany.
¹⁶ Department of Anaesthesiology, Evangelisches Diakoniekrankenhaus Freiburg, Freiburg, Germany.
¹⁷ Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Muenster, Germany.
¹⁸ Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

PMID: 36326235
PMCID: PMC9631974
DOI: 10.1093/bjsopen/zrac128

Abstract

Background: Blood transfusions are common medical procedures and every age group requires detailed insights and treatment bundles. The aim of this study was to examine the association of anaemia, co-morbidities, complications, in-hospital mortality, and transfusion according to age groups to identify patient groups who are particularly at risk when undergoing surgery.

Methods: Data from 21 Hospitals of the Patient Blood Management Network Registry were analysed. Patients were divided into age subgroups. The incidence of preoperative anaemia, co-morbidities, surgical disciplines, hospital length of stay, complications, in-hospital mortality rate, and transfusions were analysed by descriptive and multivariate regression analysis.

Results: A total of 1 117 919 patients aged 18-108 years were included. With increasing age, the number of co-morbidities and incidence of preoperative anaemia increased. Complications, hospital length of stay, and in-hospital mortality increased with age and were higher in patients with preoperative anaemia. The mean number of transfused red blood cells (RBCs) peaked, whereas the transfusion rate increased continuously. Multivariate regression analysis showed that increasing age, co-morbidities, and preoperative anaemia were independent risk factors for complications, longer hospital length of stay, in-hospital mortality, and the need for RBC transfusion.

Conclusion: Increasing age, co-morbidities, and preoperative anaemia are independent risk factors for complications, longer hospital length of stay, in-hospital mortality, and the need for RBC transfusion. Anaemia diagnosis and treatment should be established in all patients.

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Figures

**Fig. 1**
Distribution of preoperative anaemia severities according to age groups

**Fig. 2**
Perioperative complication rates according to age groups: single and composite rate of complications with 95 per cent confidence interval per age group

**Fig. 3**
In-hospital mortality rate with and without preoperative anaemia according to age groups

**Fig. 4**
RBC transfusion rate with and without preoperative anaemia according to age groups RBC, red blood cell

See this image and copyright information in PMC

References

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Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry

Collaborators

Affiliations

Association of anaemia, co-morbidities and red blood cell transfusion according to age groups: multicentre sub-analysis of the German Patient Blood Management Network Registry

Authors

Collaborators

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical