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. 2022 Dec 5;219(12):e20221334.
doi: 10.1084/jem.20221334. Epub 2022 Nov 3.

Challenges in TB research

Thomas J Scriba  1 , Ryan Dinkele  2 , Digby F Warner  2   3 , Valerie Mizrahi  2   3
Affiliations

Challenges in TB research

Thomas J Scriba et al. J Exp Med. .

Abstract

Tuberculosis (TB) is an infectious disease bedeviled by complexity. This poses myriad challenges for a research ecosystem organized around specialist host- and/or pathogen-focused thrusts. Here, we highlight the key challenges and their implications for developing new tools to control TB.

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Figures

Figure 1.
Figure 1.
The TB research ecosystem. TB is a disease fraught with complexity at every level, from the transmission, infection, and disease cycle of the host to the diverse phenotypic and genotypic variation of the pathogen. Recapitulating this complexity in a single experimental system has proven challenging, an unintended consequence being the siloing of research thrusts focusing primarily on the host (pink arrows) or the pathogen (blue arrows), seldom both, and very rarely incorporating the environments in which natural infection and disease occur.
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References

    1. Aldridge, B.B., et al. . 2021. Nat. Med. 10.1038/s41591-021-01442-2 - DOI - PubMed
    1. Cadena, A.M., et al. . 2017. Nat. Rev. Immunol. 10.1038/nri.2017.69 - DOI - PMC - PubMed
    1. Chakaya, J., et al. . 2021. Int. J. Infect. Dis. 10.1016/j.ijid.2021.02.107 - DOI
    1. Chung, E.S., et al. . 2022. Nat. Rev. Microbiol. 10.1038/s41579-022-00721-0 - DOI - PMC - PubMed
    1. Dartois, V.A., and Rubin E.J.. 2022. Nat. Rev. Microbiol. 10.1038/s41579-022-00731-y - DOI - PMC - PubMed