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. 2022 Nov;160(2):481-489.
doi: 10.1007/s11060-022-04167-5. Epub 2022 Nov 3.

Matched case-control analysis of outcomes following surgical resection of incidental meningioma

Silky Chotai  1 , Alan R Tang  2 , Rishabh Gupta  1 , Bradley S Guidry  2 , Jake R McDermott  3 , Candace J Grisham  2 , Peter J Morone  1 , Reid C Thompson  1 , Lola B Chambless  4
Affiliations

Matched case-control analysis of outcomes following surgical resection of incidental meningioma

Silky Chotai et al. J Neurooncol. 2022 Nov.

Abstract

Purpose: The management of incidentally discovered meningioma remains controversial. We sought to compare outcomes following surgical resection of incidental meningioma to a matched cohort of symptomatic meningiomas.

Methods: A retrospective single-center case-control study was conducted for patients undergoing resection of incidental meningioma from 2000 to 2019. A 1:1 case-control matching for incidental and symptomatic meningioma was performed using the following variables: age at initial visit, gender, tumor location/size, and presence of peritumoral edema. Primary outcomes included (1) WHO grading/histopathological subtype/MIB-1 index, (2) extent of resection (gross total resection or subtotal resection), and (3) recurrence. Outcomes were compared between groups using descriptive/bivariate analyses.

Results: A total of 91 incidental meningiomas were analyzed. Trauma was the most common reason (n = 19, 21%) to obtain imaging, and tumor size the leading reason to operate (n = 37, 41%). Median time-to-surgery from initial clinical encounter was 5-months (Q1:3, Q3:16.5). More incidental meningioma patients (n = 47, 52%) were privately insured compared to their matched symptomatic cohort (n = 30, 33%) (P = 0.006). Patients with incidental meningioma had significantly higher mean Karnofsky Performance Scale at time-of-surgery (93.2, SD:11.1 vs. 81.4, SD:12.7) (P < 0.001). There were no significant differences in primary/secondary outcomes between the groups. Incidental meningioma was not associated with recurrence on Cox proportional hazards analysis (HR: 0.795, 95%CI: 0.3-2.1, P = 0.637).

Conclusion: Matched case-control analysis demonstrated no significant differences in clinical, histopathological, and functional outcomes following resection of incidental and symptomatic meningioma. While non-operative management with close follow-up and serial imaging is preferred for incidental meningiomas, those undergoing resection when indicated can anticipate similar safety and efficacy as symptomatic meningiomas.

Keywords: Asymptomatic; Incidental; Meningioma; Outcomes; Symptomatic.

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