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. 2022 Nov 28;40(50):7170-7175.
doi: 10.1016/j.vaccine.2022.06.018. Epub 2022 Oct 31.

Effectiveness estimates for enhanced trivalent influenza vaccines in an aged care summer outbreak

Mohana Kunasekaran  1 , Aye Moa  2 , Elmira Hooshmand  2 , Mallory Trent  2 , Christopher J Poulos  3 , Abrar A Chughtai  4 , David J Heslop  4 , C Raina MacIntyre  2
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Effectiveness estimates for enhanced trivalent influenza vaccines in an aged care summer outbreak

Mohana Kunasekaran et al. Vaccine. .

Abstract

An influenza outbreak occurred during summer (February 2019) in an aged-care facility in Sydney, Australia. Residents had not received the annual 2019 influenza vaccine while 76.7% had received 2018 influenza vaccines about 9 months prior. Overall, 2018 influenza vaccine effectiveness during this outbreak was high (93.6%). The effectiveness of the high-dose trivalent vaccine (HD-TIV) and adjuvanted trivalent (a-TIV) vaccine were 89.8% (95% confidence interval: 18.8%-98.7%) and 72.5% (95% confidence interval: -106.7%-96.3%) respectively. The differences in effectiveness between HD-TIV, a-TIV and SD-QIV, during the summer outbreak were not significant.

Keywords: Adjuvanted trivalent vaccines; Aged care; High-dose trivalent vaccine; Influenza; Outbreak.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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