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. 2023 Jan;42(1):86-97.
doi: 10.23876/j.krcp.21.294. Epub 2022 Sep 8.

Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study

Hong Sang Choi  1 , Bongseong Kim  2 , Kyung-Do Han  2 , Tae Ryom Oh  1 , Sang Heon Suh  1 , Minah Kim  1 , Chang Seong Kim  1 , Eun Hui Bae  1 , Seong Kwon Ma  1 , Soo Wan Kim  1
Affiliations

Weight change and risk of depression in patients with diabetic kidney disease: a nationwide population-based study

Hong Sang Choi et al. Kidney Res Clin Pract. 2023 Jan.

Abstract

Background: Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However, the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease (DKD).

Methods: From the Korean National Health Insurance Service database, we selected 67,866 patients with DKD and body weight data from two consecutive health examinations with a 2-year interval between 2009 and 2012. Weight change over 2 years was categorized into five groups: ≥-10%, <-10% to ≥-5%, <-5% to <5%, ≥5% to <10%, and ≥10%. The occurrence of depression was monitored via the codes of International Statistical Classification of Diseases, 10th revision through the end of 2018.

Results: During the 5.24-year follow-up, 17,023 patients with DKD developed depression. Weight change and the risk of depression had a U-shaped relationship: patients with ≥-10% weight change (hazard ratio [HR], 1.12) and those with ≥10% weight change (HR, 1.11) showed higher HRs for depression than those with <-5% to <5% weight change, even after adjusting for several confounding factors. In the subgroup analyses, the risk of depression tended to increase as weight gain or weight loss increased in all subgroups.

Conclusion: Both weight loss and weight gain increased the risk of depression in patients with DKD.

Keywords: Depression; Diabetic nephropathies; Risk; Weight change.

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Conflict of interest statement

Conflicts of interest

All authors have no conflicts of interest to declare.

Figures

Figure 1.
Figure 1.. Flowchart of the study population.
Figure 2.
Figure 2.. HRs (95% confidence intervals) for depression according to weight change status in diabetic kidney disease patients.
HR, hazard ratio.
Figure 3.
Figure 3.. HRs (95% confidence intervals) for depression according to weight change status in subgroups.
BMI, body mass index; DM, diabetes mellitus; HR, hazard ratio; OHA, oral hypoglycemic agents.
See this image and copyright information in PMC

References

    1. ESRD Registry Committee. Korean Society of Nephrology . Current renal replacement therapy in Korea: Insan Memorial Dialysis Registry, 2016. Korean Society of Nephrology; 2017.
    1. Saran R, Robinson B, Abbott KC, et al. US renal data system 2019 annual data report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 2020;75:A6–A7. - PubMed
    1. Vallon V, Komers R. Pathophysiology of the diabetic kidney. Compr Physiol. 2011;1:1175–1232. - PMC - PubMed
    1. Thomas MC, Cooper ME, Rossing K, Parving HH. Anaemia in diabetes: is there a rationale to TREAT? Diabetologia. 2006;49:1151–1157. - PubMed
    1. Adler AI, Stevens RJ, Manley SE, et al. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64) Kidney Int. 2003;63:225–232. - PubMed

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