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Review
. 2022 Oct 18:15:960657.
doi: 10.3389/fnmol.2022.960657. eCollection 2022.

A crosstalk between circular RNA, microRNA, and messenger RNA in the development of various brain cognitive disorders

Liang He  1 , Furong Zhang  1 , Yuling Zhu  1 , Meilin Lu  2
Affiliations
Review

A crosstalk between circular RNA, microRNA, and messenger RNA in the development of various brain cognitive disorders

Liang He et al. Front Mol Neurosci. .

Abstract

Patients with Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI), stroke, and postoperative neurocognitive disorder (POND) are commonly faced with neurocognitive disorders with limited therapeutic options. Some non-coding ribonucleic acids (ncRNAs) are involved in the development of various brain cognitive disorders. Circular RNAs (circRNAs), a typical group of ncRNAs, can function as competitive endogenous RNAs (ceRNAs) to dysregulate shared microRNAs (miRNAs) at post-transcription level, inhibiting regulation of miRNAs on their targeted messenger RNAs (mRNAs). circRNAs are abundant in central nervous system (CNS) diseases and cause brain disorders, but the exact roles of circRNAs are unclear. The crosstalk between circRNA, miRNA, and mRNA plays an important role in the pathogenesis of these neurocognitive dysfunction diseases and abnormal conditions including AD, PD, stroke, TBI, and POND. In this review, we summarized the participation of circRNA in neuroglial damage and inflammation. Finally, we aimed to highlight the regulatory mechanisms of circRNA-miRNA-mRNA networks in the development of various brain cognitive disorders and provide new insights into the therapeutics of these diseases.

Keywords: ceRNA; circular RNAs; cognitive dysfunction; network; neurocognitive.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Circular RNAs (CircRNAs) act as the sponges of microRNAs (miRNAs) in neuroglial damage. Main circRNAs can act as miRNA sponges, resulting in the inhibition of miRNA on its target genes and/or proteins, and function as important roles in neuronal damage. Some circRNAs derived from extracellular vesicles (EVs) in astrocytes are beneficial for the attenuation of neurological disorders.
Figure 2
Figure 2
Regulatory networks of circRNA–miRNA–mRNA in various brain disorders. Changes in the regulatory networks of circRNA–miRNA–mRNA and potential signaling pathways are presented.
See this image and copyright information in PMC

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