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. 2023 Jun;32(3):e13775.
doi: 10.1111/jsr.13775. Epub 2022 Nov 4.

Effect of sleep disturbance on biomarkers related to the development of adverse health outcomes: A systematic review of the human literature

Kapeena Sivakumaran  1 , Jennifer A Ritonja  2   3 , Nicole Palmer  1 , Tejanth Pasumarthi  1   4 , Haya Waseem  1 , Tiffany Yu  1   5 , Allison Denning  6 , David Michaud  6 , Rebecca L Morgan  1   7
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Effect of sleep disturbance on biomarkers related to the development of adverse health outcomes: A systematic review of the human literature

Kapeena Sivakumaran et al. J Sleep Res. 2023 Jun.

Abstract

Literature suggests that unrestricted and undisturbed sleep is vital for basic human function and performance; however, it is unclear as to what amount of sleep disturbance leads to dysregulation in biomarkers, which may underscore the development of adverse health effects. This systematic review aims to identify the amount of sleep disturbance that contributes to biomarker changes as a potential precursor to the development of adverse health effects. English-language comparative studies available in PubMed, Cochrane Central, EMBASE, and CINAHL databases from 1 January 1980 to 31 July 2021 were searched. Where possible, random-effects meta-analyses were used to examine the effect of sleep disturbances on adverse health effects. The risk of bias of individual studies was assessed using the Cochrane Risk of Bias Tool and the Risk of Bias of Nonrandomised Studies - of Exposures instruments and the certainty of the body of evidence for each outcome was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. The search identified 92 primary studies reporting on blood pressure, hypertension, heart rate, cardiac arrhythmia, cardiac output, waist circumference, cortisol, adrenaline, noradrenaline, immune system markers, glucose, insulin, cholesterol, and triglyceride levels. Although some meta-analyses suggested there may be an association between sleep disturbances and certain outcomes, the certainty in the evidence was very low due to concerns with risk of bias, inconsistency across exposures, populations, and imprecision in the estimates of effects. Further research is needed to explore the point at which types, levels and duration of sleep disturbances may begin to increase the risk of developing adverse health outcomes to inform and tailor health interventions.

Keywords: GRADE; cardiovascular; meta-analysis; metabolic; stress.

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References

REFERENCES

    1. Aguayo, G. A., Pastore, J., Backes, A., Stranges, S., Witte, D. R., Diederich, N. J., … Fagherazzi, G. (2021). Objective and subjective sleep measures are associated with HbA1c and insulin sensitivity in the general population: Findings from the ORISCAV-LUX-2 study. Diabetes & Metabolism, 48, 101263. https://doi.org/10.1016/j.diabet.2021.101263
    1. Archbold, K. H., Vasquez, M. M., Goodwin, J. L., & Quan, S. F. (2012). Effects of sleep patterns and obesity on increases in blood pressure in a 5-year period: Report from the Tucson Children's assessment of sleep apnea study. The Journal of Pediatrics, 161, 26-30. https://doi.org/10.1016/j.jpeds.2011.12.034
    1. Born, J., Schenk, U., Spath-Schwalbe, E., & Fehm, H. L. (1988). Influences of partial REM sleep deprivation and awakenings on nocturnal cortisol release. Biological Psychiatry, 24, 801-811. https://doi.org/10.1016/0006-3223(88)90256-9
    1. Boutron, I., Page, M. J., Higgins, J. P. T., Altman, D. G., Lundh, A., & Hróbjartsson, A. (2021). Chapter 7: Considering bias and conflicts of interest among the included studies. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds). Cochrane handbook for systematic reviews of interventions version 6.2 (updated February 2021). Cochrane, 2021. Retrieved from http://www.training.cochrane.org/handbook
    1. Broussard, J. L., Chapotot, F., Abraham, V., Day, A., Delebecque, F., Whitmore, H. R., & Tasali, E. (2015). Sleep restriction increases free fatty acids in healthy men. Diabetologia, 58, 791-798. https://doi.org/10.1007/s00125-015-3500-4

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