Mechanistic insights from molecular microbiology into the production of immunological and neuronal diversity
- PMID: 36331175
- DOI: 10.1111/mmi.14997
Mechanistic insights from molecular microbiology into the production of immunological and neuronal diversity
Abstract
Bacteria deal with an unpredictable, and often hostile, environment by being unpredictable themselves. This article will link some contributions made by variable DNA topology and nucleoid-associated proteins to the generation of stochasticity in bacterial gene expression and describe how the associated mechanistic insights can elucidate the means by which diversity in antibody and neuronal cell development might be produced in humans and other higher organisms. The focus here will not be on mutation; instead, the article will address epigenetic effects on gene expression brought about by the modulation of topoisomerase activity in both prokaryotes and eukaryotes.
Keywords: Escherichia coli; RAG1/RAG2; TOP2β; immunodiversity; neurodiversity; type 1 fimbriae.
© 2022 The Author. Molecular Microbiology published by John Wiley & Sons Ltd.
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References
REFERENCES
-
- Abraham, J.M., Freitag, C.S., Clements, J.R. & Eisenstein, B.I. (1985) An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli. Proceedings of the National Academy of Sciences, 82, 5724-5727.
-
- Alvarez-Quilon, A., Terron-Bautista, J., Delgado-Sainz, I., Serrano-Benitez, A., Romero-Granados, R., Martinez-Garcia, P.M. et al. (2020) Endogenous topoisomerase-II-mediated DNA breaks drive thymic cancer predisposition linked to AT deficiency. Nature Communications, 11, 910.
-
- Anderson, G.G., Palermo, J.J., Schilling, J.D., Roth, R., Heuser, J. & Hultgren, S.J. (2003) Intracellular bacterial biofilm-like pods in urinary tract infections. Science, 301, 105-107.
-
- Austin, C.A., Cowell, I.G., Khazeem, M.M., Lok, D. & Ng, H.T. (2021) TOP2β's contributions to transcription. Biochemical Society Transactions, 49, 2483-2493.
-
- Baron-Cohen, S. (2020) The pattern seekers: how autism drives human invention. London: Penguin Books Ltd.
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