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Review
. 2022 Dec;24(12):1933-1944.
doi: 10.1007/s11886-022-01806-1. Epub 2022 Nov 4.

Mitral Annular Disjunction: Associated Pathologies and Clinical Consequences

Jonas Verbeke  1 , Anthony Demolder  2 , Julie De Backer #  2 , Frank Timmermans #  2
Affiliations
Review

Mitral Annular Disjunction: Associated Pathologies and Clinical Consequences

Jonas Verbeke et al. Curr Cardiol Rep. 2022 Dec.

Abstract

Purpose of review: To provide an overview of mitral annular disjunction (MAD) and to discuss important challenges in diagnosis and management of MAD.

Recent findings: MAD has regained interest in the context of sudden cardiac death (SCD) in patients with mitral valve prolapse (MVP), coined as the "arrhythmic" MVP syndrome. In addition, MAD in isolation was recently suggested to be associated with severe arrhythmia and SCD. There is a lack of consensus on the definition of MAD and the imaging modality to be used for diagnosing MAD, and the therapeutic implications of MAD remain uncertain. Furthermore, the exact mechanism underlying the association of MAD with SCD remains largely unexplored.

Keywords: Mitral annular disjunction; Mitral regurgitation; Mitral valve prolapse; Sudden cardiac death.

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References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance
    1. Freed LA, Benjamin EJ, Levy D, Larson MG, Evans JC, Fuller DL, et al. Mitral valve prolapse in the general population. J Am Coll Cardiol Foundation. 2002;40:1298–304.
    1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. The Lancet Elsevier. 2006;368:1005–11. - DOI
    1. Antoine C, Benfari G, Michelena HI, Maalouf JF, Nkomo VT, Thapa P, et al. Clinical outcome of degenerative mitral regurgitation. Circulation American Heart Association. 2018;138:1317–26.
    1. Nishimura RA, McGoon MD, Shub C, Miller FA, Ilstrup DM, Tajik AJ. Echocardiographically documented mitral-valve prolapse: long-term follow-up of 237 patients. N Engl J Med. 1985;313:1305–9. - DOI
    1. Düren DR, Becker AE, Dunning AJ. Long-term follow-up of idiopathic mitral valve prolapse in 300 patients: a prospective study. J Am Coll Cardiol Foundation. 1988;11:42–7.

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