Biocompatibility and biological activity of C₇₀ fullerene adduct with L-threonine (C₇₀(C₄H₉NO₃)₂)

Affiliations

¹ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: sharoyko@gmail.com.
² Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.
³ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.
⁴ Saint Petersburg State Technological Institute (Technical University), 26 Moskovskii Pr., Saint Petersburg, 190013, Russia.
⁵ A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia.
⁶ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: knsemenov@gmail.com.

PMID: 36332482
DOI: 10.1016/j.bbrc.2022.10.054

Biocompatibility and biological activity of C₇₀ fullerene adduct with L-threonine (C₇₀(C₄H₉NO₃)₂)

Vladimir V Sharoyko et al. Biochem Biophys Res Commun. 2022.

. 2022 Dec 25;636(Pt 1):50-56.

doi: 10.1016/j.bbrc.2022.10.054. Epub 2022 Oct 19.

Affiliations

¹ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: sharoyko@gmail.com.
² Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.
³ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia.
⁴ Saint Petersburg State Technological Institute (Technical University), 26 Moskovskii Pr., Saint Petersburg, 190013, Russia.
⁵ A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia.
⁶ Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address: knsemenov@gmail.com.

PMID: 36332482
DOI: 10.1016/j.bbrc.2022.10.054

Abstract

The aim of this work is to synthesise and study the biocompatibility and biological activity of the C₇₀ fullerene adduct with l-threonine (C₇₀-Thr). The obtained adduct was identified using a complex of physicochemical methods, namely, ¹³C NMR spectroscopy, IR spectroscopy, thermogravimetric analysis, electron spectroscopy, elemental analysis, and high-performance liquid chromatography. The study of biocompatibility and biological activity of the C₇₀-Thr adduct included the study of haemocompatibility (haemolysis, platelet aggregation, plasma coagulation haemostasis, binding to human serum albumin, esterase activity), antiradical activity, cytotoxicity, cell proliferation, and interaction with DNA (determination of the DNA binding constant and genotoxicity).

Keywords: Biocompatibility; Biological activity; DPPH; Fullerene; HSA; l-threonine.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Biocompatibility and biological activity of C₇₀ fullerene adduct with L-threonine (C₇₀(C₄H₉NO₃)₂)

Affiliations

Biocompatibility and biological activity of C₇₀ fullerene adduct with L-threonine (C₇₀(C₄H₉NO₃)₂)

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Abstract

Conflict of interest statement

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