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. 2022 Nov 3;30(11):1467-1469.
doi: 10.1016/j.str.2022.09.007.

Pulling the wool over a pathogen's eyes: Llama nanobody inhibitors of the bacterial SOS response

Edwin Chen  1 , Matthew J Culyba  2
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Pulling the wool over a pathogen's eyes: Llama nanobody inhibitors of the bacterial SOS response

Edwin Chen et al. Structure. .
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Abstract

In this issue of Structure, Maso et al. (2022) discover nanobodies that inhibit the SOS response of Escherichia coli by targeting the LexA repressor-protease. High-resolution structures of the novel LexA-nanobody complexes reveal they function by stabilizing LexA in its inactive conformation and preventing co-proteolysis by RecA∗.

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