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Comment
. 2022 Nov 14;40(11):1269-1270.
doi: 10.1016/j.ccell.2022.10.003. Epub 2022 Nov 3.

Could SIRPA expression predict response to anti-PD-1 immunotherapy?

Kristen Jogerst  1 , Genevieve Boland  2
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Could SIRPA expression predict response to anti-PD-1 immunotherapy?

Kristen Jogerst et al. Cancer Cell. .
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Abstract

Immune checkpoint inhibitors (ICIs) offer significant promise for patients with melanoma; however, many patients succumb to de novo or acquired ICI resistance. In this issue of Cancer Cell, Zhou et al. propose a mechanism for signal-regulatory protein α1 (SIRPα) expression and describe how its loss may contribute to immunotherapy resistance.

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