Helper T Cell 17 and Regulatory T Cell Levels in Peripheral Blood of Newly Diagnosed Patients with Autoimmune Thyroid Disease: A Meta-Analysis
- PMID: 36332627
- DOI: 10.1055/a-1972-5787
Helper T Cell 17 and Regulatory T Cell Levels in Peripheral Blood of Newly Diagnosed Patients with Autoimmune Thyroid Disease: A Meta-Analysis
Erratum in
-
Correction: Helper T Cell 17 and Regulatory T Cell Levels in Peripheral Blood of Newly Diagnosed Patients with Autoimmune Thyroid Disease: A Meta-Analysis.Horm Metab Res. 2023 Jan;55(1):e2. doi: 10.1055/a-2117-7652. Epub 2023 Jul 6. Horm Metab Res. 2023. PMID: 37414084 No abstract available.
Abstract
This article aims to explore associated immune indicators of autoimmune thyroid disease (AITD) through a meta-analysis of published case-control studies on newly diagnosed AITD patients, intending to provide some suggestions for research on the mechanisms of AITD. Six electronic databases were searched for case-control studies on newly diagnosed AITD patients from inception to August 15, 2022. A random-effects model was used to calculate the standardized mean difference (SMD), odds ratio (OR), and 95% confidence interval (95% CI). A total of 26 articles were included in this meta-analysis. Patients with newly diagnosed AITD had higher levels of helper T cell 17 (Th17) (Hashimoto's disease (HT): SMD=2.35, 95% CI: 1.98, 2.72; Graves' disease (GD): SMD=1.61, 95% CI: 1.23, 1.98), lower levels of regulatory T cell (Treg) (HT: SMD=-2.04, 95% CI: -2.67, -1.42; GD: SMD=-1.35, 95% CI: -2.11, -0.58), and lower levels of forkhead box P3 (FoxP3) mRNA (HT: SMD=-2.58, 95% CI: -3.12, -2.05; GD: SMD=-2.13, 95% CI: -2.56, -1.70), compared to the healthy population. In addition, the single nucleotide polymorphism rs3761548 and rs3761549 in the promoter region of FoxP3 showed a higher frequency in the comparison of genotype "CT" only in HT patients than in the healthy population (OR=1.66, 95%CI: 1.18, 2.34). In patients with newly diagnosed AITD, the Th17/Treg ratio imbalance may develop AITD. Monitoring Th17 and Treg levels may become an essential tool to assess the organism's immune homeostasis and hopefully guide clinical diagnosis and treatment.
Thieme. All rights reserved.
Conflict of interest statement
The authors declare that they have no conflict of interest.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources