Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 4;12(1):18730.
doi: 10.1038/s41598-022-21852-7.

Risk of cardiovascular disease and mortality in patients with diabetes and acute pancreatitis history: a nationwide cohort study

Dong Kee Jang #  1 , Jin Ho Choi #  2 , Woo Hyun Paik  2 , Ji Kon Ryu  2 , Yong-Tae Kim  2 , Kyung-Do Han  3 , Sang Hyub Lee  4
Affiliations

Risk of cardiovascular disease and mortality in patients with diabetes and acute pancreatitis history: a nationwide cohort study

Dong Kee Jang et al. Sci Rep. .

Abstract

Patients with acute pancreatitis (AP) may have an increased risk of cardiovascular disease (CVD). Few studies have dealt with the association between AP and the risk of CVD in diabetic patients. This study aimed to investigate the risk of CVD and mortality in patients with diabetes and AP history by analyzing a large-scale national claims database in Korea. Data from the Korean National Health Insurance Service database was analyzed. A total of 2,746,988 participants with type 2 diabetes mellitus that underwent a general health examination between 2009 and 2012 were enrolled. The participants were divided into two groups according to AP history (yes or no) prior to the examination date, and follow-up data until 2018 was analyzed. The primary endpoint was the occurrence of stroke, myocardial infarction (MI), or death. The Cox proportional hazards regression analysis was used to evaluate the association between AP history and the risk of stroke, MI, and mortality. After exclusion, the included number of participants with and without AP history were 3,810 and 2,258,910, respectively. The presence of AP history showed a significantly higher incidence of stroke, MI, and mortality. The adjusted hazard ratios (95% confidence interval) for the risk of stroke, MI, and mortality were 1.534 (1.342-1.753), 1.998 (1.733-2.303), and 2.353 (2.200-2.515), respectively. Age < 65, male sex, current smoking, and drinking significantly increased the risk of death in the subgroup analyses. The risk of stroke, MI, and mortality was significantly higher in diabetic participants with AP history than those without AP history at 9-year follow-up. This suggests that active management of cardiovascular risk factors is necessary in diabetic patients with AP history.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier curves for the risk of cardiovascular disease and mortality according to acute pancreatitis history. The curves display the cumulative incidence probability of (A) stroke, (B) myocardial infarction, and (C) mortality.
Figure 2
Figure 2
Forest plots for the risk of cardiovascular disease and mortality in subgroup analyses. (A) HR of stroke, (B) HR of myocardial infarction, and (C) HR of mortality.
Figure 2
Figure 2
Forest plots for the risk of cardiovascular disease and mortality in subgroup analyses. (A) HR of stroke, (B) HR of myocardial infarction, and (C) HR of mortality.
See this image and copyright information in PMC

References

    1. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM, Jensen ET, Lund JL, Pasricha S, Runge T, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015;149(7):1731–1741. doi: 10.1053/j.gastro.2015.08.045. - DOI - PMC - PubMed
    1. Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA., Jr Increasing United States hospital admissions for acute pancreatitis, 1988–2003. Ann. Epidemiol. 2007;17(7):491–497. doi: 10.1016/j.annepidem.2007.02.002. - DOI - PubMed
    1. Krishna SG, Kamboj AK, Hart PA, Hinton A, Conwell DL. The changing epidemiology of acute pancreatitis hospitalizations: A decade of trends and the impact of chronic pancreatitis. Pancreas. 2017;46(4):482–488. doi: 10.1097/MPA.0000000000000783. - DOI - PMC - PubMed
    1. Johnson CD, Abu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut. 2004;53(9):1340–1344. doi: 10.1136/gut.2004.039883. - DOI - PMC - PubMed
    1. Sung LC, Chang CC, Lin CS, Yeh CC, Cherng YG, Chen TL, Liao CC. Risk of acute atherosclerotic cardiovascular disease in patients with acute and chronic pancreatitis. Sci. Rep. 2021;11(1):20907. doi: 10.1038/s41598-021-99915-4. - DOI - PMC - PubMed