Impact of tablet crushing on the dissolution of venetoclax

Takeo Yasu^{1

2

3}, Eri Hikita⁴, Yoshito Gando⁵, Moyumi Odate⁶, Motoki Inoue⁶, Mikio Shirota^{4

7}

Affiliations

¹ Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan. yasutakeo-tky@umin.ac.jp.
² Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan. yasutakeo-tky@umin.ac.jp.
³ Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan. yasutakeo-tky@umin.ac.jp.
⁴ Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan.
⁵ Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan.
⁶ Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan.
⁷ Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan.

Takeo Yasu et al. Ann Hematol. 2023 Jan.

. 2023 Jan;102(1):219-220.

doi: 10.1007/s00277-022-05014-3. Epub 2022 Nov 4.

Takeo Yasu^{1

2

3}, Eri Hikita⁴, Yoshito Gando⁵, Moyumi Odate⁶, Motoki Inoue⁶, Mikio Shirota^{4

7}

¹ Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan. yasutakeo-tky@umin.ac.jp.
² Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan. yasutakeo-tky@umin.ac.jp.
³ Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan. yasutakeo-tky@umin.ac.jp.
⁴ Department of Pharmacy, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan.
⁵ Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan.
⁶ Department of Molecular Pharmaceutics, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo, 204-8588, Japan.
⁷ Bokutoh Hospital-Meiji Pharmaceutical University Joint Research Center, 4-23-15 Koutoubashi, Sumida-Ku, Tokyo, 130-8575, Japan.

No abstract available

References

1. Anzai M, Yasu T, Gando Y, Shirota M, Kobayashi M (2022) Increased blood levels of venetoclax due to intake of crushed venetoclax tablets. Ann Hematol 101(9):2097–2098. https://doi.org/10.1007/s00277-022-04871-2 - DOI
1. Yasu T, Gando Y, Nomura Y, Kosugi N, Kobayashi M (2022) Determination of venetoclax concentration in plasma using high-performance liquid chromatography. J Chromatogr Sci:bmac027. https://doi.org/10.1093/chromsci/bmac027
1. Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48(3):452–458. https://doi.org/10.1038/bmt.2012.244 - DOI
1. Jermain SV, Brough C, Williams RO 3rd (2018) Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery - an update. Int J Pharm 535(1–2):379–392. https://doi.org/10.1016/j.ijpharm.2017.10.051 - DOI
1. Pas T, Verbert S, Appeltans B, Van den Mooter G (2020) The influence of crushing amorphous solid dispersion dosage forms on the in-vitro dissolution kinetics. Int J Pharm 573:118884. https://doi.org/10.1016/j.ijpharm.2019.118884 - DOI