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Review
. 2022 Nov 5;195(1):75.
doi: 10.1007/s10661-022-10564-0.

Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review

Sonam Tripathi  1 , Diane Purchase  2 , Muthusamy Govarthanan  3 , Ram Chandra  4 , Sangeeta Yadav  5   6
Affiliations
Review

Regulatory and innovative mechanisms of bacterial quorum sensing-mediated pathogenicity: a review

Sonam Tripathi et al. Environ Monit Assess. .

Abstract

Quorum sensing (QS) is a system of bacteria in which cells communicate with each other; it is linked to cell density in the microbiome. The high-density colony population can provide enough small molecular signals to enable a range of cellular activities, gene expression, pathogenicity, and antibiotic resistance that cause damage to the hosts. QS is the basis of chronic illnesses in human due to microbial sporulation, expression of virulence factors, biofilm formation, secretion of enzymes, or production of membrane vesicles. The transfer of antimicrobial resistance gene (ARG) among antibiotic resistance bacteria is a major public health concern. QS-mediated biofilm is a hub for ARG horizontal gene transfer. To develop innovative approach to prevent microbial pathogenesis, it is essential to understand the role of QS especially in response to environmental stressors such as exposure to antibiotics. This review provides the latest knowledge on the relationship of QS and pathogenicity and explore the novel approach to control QS via quorum quenching (QQ) using QS inhibitors (QSIs) and QQ enzymes. The state-of-the art knowledge on the role of QS and the potential of using QQ will help to overcome the threats of rapidly emerging bacterial pathogenesis.

Keywords: Acylated homoserine lactone; Antibiotic sensitivity; Auto-inducers; Biofilm formation; Pathogenicity; Quorum quenching; Quorum sensing.

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References

    1. Alav, I., Kobylka, J., Kuth, M. S., Pos, K. M., Picard, M., Blair, J. M. A., & Bavro, V. N. (2021). Structure, assembly, and function of tripartite efflux and type 1 secretion systems in Gram-negative bacteria. Chemical Reviews, 121(9), 5479–5596.
    1. Algburi, A., Asghar, A., Huang, Q., Mustfa, W., Javed, H. U., Zehm, S., & Chikindas, M. L. (2021). Black cardamom essential oil prevents Escherichia coli O157: H7 and Salmonella Typhimurium JSG 1748 biofilm formation through inhibition of quorum sensing. Journal of Food Science and Technology, 58(8), 3183–3191.
    1. Ameen, F., AlYahya, S., Govarthanan, M., ALjahdali, N., Al-Enazi, N., Alsamhary, K., & Alharbi, S. A. (2020). Soil bacteria Cupriavidus sp. mediates the extracellular synthesis of antibacterial silver nanoparticles. Journal of Molecular Structure, 1202, 127233.
    1. Ana, C., Reis, B. A., Kolvenbach, O. C., & Nunes, P. F. X. (2020). Biodegradation of antibiotics: The new resistance determinants – part I. New Biotech., 54, 34–51.
    1. Andersen, L. P., Marlene, H., & Jakob, J. (2017). Risk of getting nosocomial water-borne infections from the main water systems in hospitals. Journal of Life Sciences, 11, 1–10.

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