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. 2023 Feb;84(2):67-68.
doi: 10.1016/j.humimm.2022.10.008. Epub 2022 Nov 3.

HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 allele frequencies of North Tanzanian Maasai

Amber Barton  1 , Athumani Ramadhani  2 , Elias Mafuru  2 , Tara Mtuy  3 , Patrick Massae  2 , Aiweda Malissa  2 , Tamsyn Derrick  3 , Joanna Houghton  1 , Anna Harte  1 , Thomas Payne  1 , Harry Pickering  1 , Matthew J Burton  1 , Chrissy H Roberts  1 , Martin J Holland  4
Affiliations

HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 allele frequencies of North Tanzanian Maasai

Amber Barton et al. Hum Immunol. 2023 Feb.

Abstract

Locus-specific amplicon sequencing was used to HLA type 336 participants of Maasai ethnicity at the HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci. Participants were recruited from three study villages in North Tanzania, for the purpose of investigating risk factors for trachomatous scarring in children. Other than HLA-A, all loci significantly deviated from Hardy-Weinberg equilibrium, possibly due to high relatedness between individuals: 238 individuals shared a house with at least one another participant. The most frequent allele for each locus were A*68:02 (14.3 %), B*53:01 (8.4 %), C*06:02 (19.2 %), DRB1*13:02 (17.7 %), DQB1*02:01 (16.9 %) and DPB1*01:01 (15.7 %), while the most common inferred haplotype was A*68:02 ∼ B*18:01 ∼ C*07:04 ∼ DRB1*08:04 ∼ DQB1*04:02 ∼ DPB1*04:01 (1.3 %).

Keywords: HLA; Immunogenetics; MHC; Maasai; Tanzania.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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