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Comment
. 2022 Dec;8(12):973-975.
doi: 10.1016/j.trecan.2022.10.008. Epub 2022 Nov 3.

Ancestry-defined molecular taxonomy of prostate cancer

Isra Elhussin  1 , Clayton Yates  2
Affiliations
Comment

Ancestry-defined molecular taxonomy of prostate cancer

Isra Elhussin et al. Trends Cancer. 2022 Dec.

Abstract

Recent studies by Gong et al. and Jaratlerdsiri et al. re-evaluate the mutational landscape of prostate cancer (PCa) in a global context based on ancestry. These two studies revealed African-specific PCa taxonomy, including novel oncogenic drivers with promising therapeutic targets and the opportunity to predict patient outcomes using a unified pipeline.

Keywords: African ancestry; genomic alterations; prostate cancer.

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Conflict of interest statement

Declaration of interest During the writing of this report, C.Y. received personal fees from Riptide Biosciences, QED Therapeutics, and Amgen, and other income from Riptide Biosciences outside the submitted work.

Comment on

  • African-specific molecular taxonomy of prostate cancer.
    Jaratlerdsiri W, Jiang J, Gong T, Patrick SM, Willet C, Chew T, Lyons RJ, Haynes AM, Pasqualim G, Louw M, Kench JG, Campbell R, Horvath LG, Chan EKF, Wedge DC, Sadsad R, Brum IS, Mutambirwa SBA, Stricker PD, Bornman MSR, Hayes VM. Jaratlerdsiri W, et al. Nature. 2022 Sep;609(7927):552-559. doi: 10.1038/s41586-022-05154-6. Epub 2022 Aug 31. Nature. 2022. PMID: 36045292 Free PMC article.
  • Genome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers.
    Gong T, Jaratlerdsiri W, Jiang J, Willet C, Chew T, Patrick SM, Lyons RJ, Haynes AM, Pasqualim G, Brum IS, Stricker PD, Mutambirwa SBA, Sadsad R, Papenfuss AT, Bornman RMS, Chan EKF, Hayes VM. Gong T, et al. Genome Med. 2022 Aug 31;14(1):100. doi: 10.1186/s13073-022-01096-w. Genome Med. 2022. PMID: 36045381 Free PMC article.

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