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. 2023 Mar;15(1):88-99.
doi: 10.1007/s12539-022-00542-y. Epub 2022 Nov 6.

BMPMDA: Prediction of MiRNA-Disease Associations Using a Space Projection Model Based on Block Matrix

Yi Shen  1 , Jin-Xing Liu  1 , Meng-Meng Yin  1 , Chun-Hou Zheng  2 , Ying-Lian Gao  3
Affiliations

BMPMDA: Prediction of MiRNA-Disease Associations Using a Space Projection Model Based on Block Matrix

Yi Shen et al. Interdiscip Sci. 2023 Mar.

Abstract

With the high-quality development of bioinformatics technology, miRNA-disease associations (MDAs) are gradually being uncovered. At present, convenient and efficient prediction methods, which solve the problem of resource-consuming in traditional wet experiments, need to be further put forward. In this study, a space projection model based on block matrix is presented for predicting MDAs (BMPMDA). Specifically, two block matrices are first composed of the known association matrix and similarity to increase comprehensiveness. For the integrity of information in the heterogeneous network, matrix completion (MC) is utilized to mine potential MDAs. Considering the neighborhood information of data points, linear neighborhood similarity (LNS) is regarded as a measure of similarity. Next, LNS is projected onto the corresponding completed association matrix to derive the projection score. Finally, the AUC and AUPR values for BMPMDA reach 0.9691 and 0.6231, respectively. Additionally, the majority of novel MDAs in three disease cases are identified in existing databases and literature. It suggests that BMPMDA can serve as a reliable prediction model for biological research.

Keywords: Association prediction; Disease; Linear neighborhood similarity; Matrix completion; MiRNA.

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