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. 2022 Nov 5;41(1):38.
doi: 10.1186/s40101-022-00312-1.

ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population

Kathleen Yasmin De Almeida  1 , Mika Saito  1 , Hiroki Homma  1 , Yukina Mochizuki  1 , Aoto Saito  1 , Minoru Deguchi  1 , Ayumu Kozuma  1 , Takanobu Okamoto  1 , Koichi Nakazato  1 , Naoki Kikuchi  2
Affiliations

ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population

Kathleen Yasmin De Almeida et al. J Physiol Anthropol. .

Abstract

Purpose: The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which is exclusive to the Asian population, is related to many diseases. A high reactive oxygen species production in mitochondria, and low muscle strength in athletes and non-athletes, has been observed, as our previous study demonstrated. The purpose of this research was to investigate the influence of ALDH2 rs671 on the loss of muscle strength with aging and replicate our previous study in non-athletes.

Methods: Healthy Japanese individuals (n = 1804) aged 23-94 years were genotyped using DNA extracted from saliva. Muscle strength was assessed using grip strength and chair stand test (CST). The interaction between age and genotypes was analyzed by two-way analysis of covariance (ANCOVA) adjusted for sex, body mass index (BMI), and exercise habit.

Results: Individuals aged ≧55 with the AA genotype had a lower performance than those with the GG + GA genotype in the grip strength test (28.1 ± 9.1 kg vs. 29.1 ± 8.3 kg, p = 0.021). There was an interaction between age and genotype, where individuals with ≧55 years old AA genotype had a higher loss of strength compared to GG + GA genotypes in the CST (0.025). No interaction in other models and no sex differences were found.

Conclusion: This study replicated previous results of the relationship between the AA genotype with lower muscle strength and as a novelty showed that this genotype is associated with a higher age-related loss of strength.

Keywords: Mitochondrial ROS; Mitochondrial aldehyde dehydrogenase 2; Muscle strength; Oxidative stress; Sarcopenia.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Relationship between the aldehyde dehydrogenase 2 (ALDH2) genotypes and age group for the grip strength (A) and chair stand test (B)
See this image and copyright information in PMC

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