Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 15:373:577992.
doi: 10.1016/j.jneuroim.2022.577992. Epub 2022 Oct 27.

K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis

Claudia Cutellè  1 , Claudia Balducci  2 , Diletta Cereda  2 , Maria Letizia Fusco  2 , Davide Iacobucci  3 , Jacopo Perugini  3 , Fiammetta Pirro  3 , Rinaldo Brivio  4 , Davide Paolo Bernasconi  5 , Carlo Ferrarese  6 , Maura Frigo  2 , Guido Cavaletti  6
Affiliations

K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis

Claudia Cutellè et al. J Neuroimmunol. .

Abstract

The aim of the present study is to evaluate the composite role of k index in the initial assessment of Multiple Sclerosis (MS) patients and to select useful cut-offs exportable in clinical practice. We analysed CSF/serum samples of 140 patients and followed-up the CIS/MS subgroup for 7 years. Our results suggest κ index as a quantitative diagnostic and prognostic biomarker in MS, significantly associated to baseline lesion load and to successive clinical course. We propose k index ≥106 as a prognostic cut-off to select patients at major risk of relapse, potentially influencing initial therapeutic decisions.

Keywords: Biomarkers; Cerebrospinal fluid; Immunoglobulin free light chains; Multiple Sclerosis; Prognosis; κ index.

PubMed Disclaimer

LinkOut - more resources