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Review
. 2022 Dec:111:102480.
doi: 10.1016/j.ctrv.2022.102480. Epub 2022 Nov 1.

Advances in immunotherapy for MMR proficient colorectal cancer

Hazel Lote  1 , Naureen Starling  2 , Rille Pihlak  3 , Marco Gerlinger  4
Affiliations
Free article
Review

Advances in immunotherapy for MMR proficient colorectal cancer

Hazel Lote et al. Cancer Treat Rev. 2022 Dec.
Free article

Abstract

Survival in mismatch-repair proficient (MMRp) metastatic colorectal cancer (mCRC) remains poor and chemotherapy is the mainstay of treatment. Immunotherapy has demonstrated durable responses and a favourable side-effect profile in various cancer types and multiple clinical trials have been conducted in MMRp mCRC. In this review we summarise emerging trial data which demonstrate promising immunotherapy combinations in MMRp mCRC. We outline barriers to success, evaluate emerging biomarkers and discuss potential strategies to increase the effectiveness of immunotherapy in MMRp mCRC.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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