Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar;63(3-4):257-275.
doi: 10.1002/jobm.202200280. Epub 2022 Nov 6.

Bacterial cellulose: Strategies for its production in the context of bioeconomy

André R F da Silva Rocha  1 , Bárbara Côgo Venturim  1 , Elena R A Ellwanger  2 , Caroline S Pagnan  2 , Wendel B da Silveira  3 , José Guilherme P Martin  1
Affiliations
Review

Bacterial cellulose: Strategies for its production in the context of bioeconomy

André R F da Silva Rocha et al. J Basic Microbiol. 2023 Mar.

Abstract

Bacterial cellulose has advantages over plant-derived cellulose, which make its use for industrial applications easier and more profitable. Its intrinsic properties have been stimulating the global biopolymer market, with strong growth expectations in the coming years. Several bacterial species are capable of producing bacterial cellulose under different culture conditions; in this context, strategies aimed at metabolic engineering and several possibilities of carbon sources have provided opportunities for the bacterial cellulose's biotechnological exploration. In this article, an overview of biosynthesis pathways in different carbon sources for the main producing microorganisms, metabolic flux under different growth conditions, and their influence on the structural and functional characteristics of bacterial cellulose is provided. In addition, the main industrial applications and ways to reduce costs and optimize its production using alternative sources are discussed, contributing to new insights on the exploitation of this biomaterial in the context of the bioeconomy.

Keywords: acetic acid bacteria; biomaterial; biopolymer; biotechnology; fermentation.

PubMed Disclaimer

References

REFERENCES

    1. Du H, Liu W, Zhang M, Si C, Zhang X, Li B. Cellulose nanocrystals and cellulose nanofibrils based hydrogels for biomedical applications. Carbohydr Polymers. 2019;209:130-44.
    1. Liu W, Du H, Zhang M, Liu K, Liu H, Xie H, et al. Bacterial cellulose-based composite scaffolds for biomedical applications: a review. ACS Sustain Chem Eng. 2020;8:7536-62.
    1. Thiruvengadam V, Vitta S. Bacterial cellulose based flexible multifunctional nanocomposite sheets. Cellulose. 2017;24:3341-51.
    1. Mondal MIH. Mechanism of structure formation of microbial cellulose during nascent stage. Cellulose. 2013;20:1073-88.
    1. Wang H, Xie H, Du H, Wang X, Liu W, Duan Y, et al. Highly efficient preparation of functional and thermostable cellulose nanocrystals via H2SO4 intensified acetic acid hydrolysis. Carbohydr Polymers. 2020;239:116233.

LinkOut - more resources