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Case Reports
. 2022 Oct 31:10:2050313X221135232.
doi: 10.1177/2050313X221135232. eCollection 2022.

Imaging findings of two patients with isolated infarction of the splenium during COVID-19

Volkan Kızılgöz  1 , Mecit Kantarci  1   2 , Şevket Kahraman  1
Affiliations
Case Reports

Imaging findings of two patients with isolated infarction of the splenium during COVID-19

Volkan Kızılgöz et al. SAGE Open Med Case Rep. .

Abstract

Coronavirus disease 2019 (COVID-19) is caused by the virus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In the literature, this virus has been associated with coagulation dysfunction and arterial thromboembolism. In clinical practice, corpus callosum infarcts are very rare, and the incidence of isolated splenium infarct is very low. Here, two cases of isolated splenium infarct after COVID-19 are reported with clinical and imaging findings. These findings are thought to be useful in daily practice for our colleagues. In addition, differential diagnoses of this entity will also be discussed in this case report.

Keywords: COVID-19; cerebral infarction; corpus callosum; magnetic resonance imaging.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
This three-dimensional illustration is a reminder of some important anatomical structures in the callosal–pericallosal area and important vessels around the corpus callosum. The magnified image demonstrates an isolated splenium infarct due to posterior pericallosal artery occlusion (yellow arrows). Figure 1 has been created by the Adobe Photoshop program (Adobe Inc., 2021. Adobe Photoshop, https://www.adobe.com/products/photoshop.html) based on the figures provided by the Complete Anatomy program (3D4 Medical, 2021. Complete Anatomy. Retrieved from https://3d4medical.com/). Spl: splenium; PCalA: pericallosal artery; CMA: callosomarginal artery; ACA: anterior cerebral artery; PCA: posterior cerebral artery; PtPCalA: posterior pericallosal artery.
Figure 2.
Figure 2.
Magnetic resonance (MR) images of Case 1 (19-year-old female with isolated splenium infarct after COVID-19 infection). There is a slightly hypodense area in the location of splenium in T1-weighted images ((a) and (b)) and hyperintensity in the same location on axial T2-weighted images. There was no contrast medium enhancement in splenium on T1-weighted axial ((e) and (f)) and sagittal (g) series. T2-weighted sagittal image indicated the lesion in splenium with high signal intensity as well as axial FLAIR images ((i) and (j)). MR angiography shows the discontinuity of the right posterior cerebral artery on consecutive axial images ((k) and (l)). Diffusion-weighted images depict the diffusion restriction of splenium ((m) and (n)) with apparent diffusion coefficient maps ((o) and (p)).
Figure 3.
Figure 3.
Magnetic resonance (MR) images of Case 2 (22-year-old female with isolated splenium infarct after COVID-19 infection). Sagittal T1-weighted image (a) shows no pathological signal in splenium; however, sagittal T2-weighted images indicate the focal hyperintensity of the splenium (b).
See this image and copyright information in PMC

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