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Comment
. 2022:2:44.
doi: 10.20517/jca.2022.33. Epub 2022 Aug 5.

YAP/TAZ dull the STING of aging

Jamie Francisco  1 , Dominic P Del Re  1
Affiliations
Comment

YAP/TAZ dull the STING of aging

Jamie Francisco et al. J Cardiovasc Aging. 2022.
No abstract available

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Conflict of interest statement

Conflicts of interest Both authors declare no conflicts of interest.

Figures

Figure 1.
Figure 1.
A scheme representing YAP/TAZ mediated repression of cellular senescence. Under physiological aging conditions, mechanotransduction and subsequent YAP/TAZ activity are decreased, leading to the decreased expression of ACTR2 and lamin B1, two direct transcriptional targets of YAP/TAZ. The downregulation of ACTR2 and lamin B1 elicits a decline in the structural integrity of the nuclear envelope and the release of genomic DNA into the cytosol, which triggers the activation of cGAS-cGAMP-STING signaling. cGAS-STING was shown to mediate hallmarks of cellular senescence, including SASP, during aging. Created using BioRender.com.
See this image and copyright information in PMC

Comment on

  • YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING.
    Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S. Sladitschek-Martens HL, et al. Nature. 2022 Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6. Epub 2022 Jun 29. Nature. 2022. PMID: 35768505 Free PMC article.

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