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Review
. 2022 Oct 19:13:1029890.
doi: 10.3389/fmicb.2022.1029890. eCollection 2022.

Role of gut microbiota in the pathogenesis and treatment of diabetes mullites: Advanced research-based review

Junjun Ye  1   2 , Zezhen Wu  1   3 , Yifei Zhao  4 , Shuo Zhang  1   3 , Weiting Liu  4 , Yu Su  5
Affiliations
Review

Role of gut microbiota in the pathogenesis and treatment of diabetes mullites: Advanced research-based review

Junjun Ye et al. Front Microbiol. .

Abstract

Gut microbiota plays an important role in the proper functioning of human organisms, while its dysbiosis is associated with disease in various body organs. Diabetes mellitus (DM) is a set of heterogeneous metabolic diseases characterized by hyperglycemia caused by direct or indirect insulin deficiency. There is growing evidence that gut microbiota dysbiosis is closely linked to the development of DM. Gut microbiota composition changes in type 1 diabetes mullites (T1DM) and type 2 diabetes mullites (T2DM) patients, which may cause gut leakiness and uncontrolled entry of antigens into the circulation system, triggering an immune response that damages the isle β cells or metabolic disorders. This review summarizes gut microbiota composition in healthy individuals and compares it to diabetes mullites patients. The possible pathogenesis by which gut microbiota dysbiosis causes DM, particularly gut leakiness and changes in gut microbiota metabolites is also discussed. It also presents the process of microbial-based therapies of DM.

Keywords: gut leakiness; gut microbiota; gut microbiota metabolites; microbiological therapy; type 1 diabetes mullites; type 2 diabetes mullites.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Diseases caused by gut microbiota dysbiosis.
Figure 2
Figure 2
The role of gut microbiota dysbiosis in the development of diabetes mullites.
See this image and copyright information in PMC

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